Cardiolipin antibodies dependant on beta2-glycoprotein-I in antiphospholipid syndrome

被引：0

作者：

Kuznetsova, TV ^{[1
]}

Tischenko, VA ^{[1
]}

Kobylyansky, AG ^{[1
]}

Palkeeva, ME ^{[1
]}

Novikov, AA ^{[1
]}

Reshetnyak, TM ^{[1
]}

Klyukvina, NG ^{[1
]}

Nasonov, EL ^{[1
]}

机构：

[1] AL Myasnikov Clin Cardiol Inst, Moscow, Russia

来源：

TERAPEVTICHESKII ARKHIV | 1999年 / 71卷 / 12期

关键词：

antiphospholipid syndrome; beta2-glycoprotein-I; anticardiolipin antibodies;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. To study beta2-GP-I-dependant binding of phospholipid antibodies (PAb) to phospholipids and this process participation in pathogenesis of antiphospholipid syndrome (APS). Materials and methods. IgG-fractions and sera from 20 patients with APS. Cofactor activity of beta2-GP-I isolated from serum of healthy donors was examined with modified immunoassay. Results. Contrary to donor IgG, binding of IgG fractions isolated from sera of APS patients with cardiolipin grows dose-dependently in the presence of beta2-GP-I. Cofactor activity of beta2-GP-I is confirmed in the study of sera of APS patients. Sera containing beta2-GP-I-dependant antibodies to cardiolipin (aCL), unlike a CL-negative sera, react with solid-phase immobilized beta2-GP-I. Conclusion. It is confirmed that beta2-GP-I participates in interaction of PAb with cardiolipin. Pathogenetic implication of beta2-GP-I-dependant PAb for onset of APS is discussed.

引用

页码：41 / 44

页数：4

共 50 条

[1] Antibodies to phosphatidylserine/prothrombin complex in suspected antiphospholipid syndrome in the absence of antibodies to cardiolipin or Beta-2-glycoprotein I
Sanfelippo, M. J.
Joshi, A.
Schwartz, S. L.
Meister, J. A.
Goldberg, J. W.
LUPUS, 2013, 22 (13) : 1349 - 1352
[2] BETA2-GLYCOPROTEIN-I
KANDIAH, DA
KRILIS, SA
LUPUS, 1994, 3 (04) : 207 - 212
[3] Effect of synthetic peptide fragments of β2-glycoprotein-I on the binding of antiphospholipid antibodies to cardiolipin-glycoprotein-I on the binding of antiphospholipid antibodies to cardiolipin
T. V. Kuznetsova
V. A. Tishchenko
A. G. Kobylyanskii
M. E. Pal'keeva
M. V. Sidorova
Zh. D. Bespalova
E. L. Nasonov
Bulletin of Experimental Biology and Medicine, 1999, 127 : 44 - 46
[4] Novel Insights Into Associations of Antibodies Against Cardiolipin and beta2-glycoprotein I with Clinical Features of Antiphospholipid Syndrome
O. Shovman
B. Gilburd
O. Barzilai
P. Langevitz
Y. Shoenfeld
Clinical Reviews in Allergy & Immunology, 2007, 32 : 145 - 152
[5] Novel insights into associations of antibodies against cardiolipin and beta2-glycoprotein I with clinical features of antiphospholipid syndrome
Shovinan, O.
Gilburd, B.
Barzilai, O.
Langevitz, P.
Shoenfeld, Y.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2007, 32 (02) : 145 - 152
[6] ANTIBODIES TO BETA-2-GLYCOPROTEIN-I IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME
PENGO, V
BIASIOLO, A
FIOR, MG
TONETTO, S
RUFFATTI, A
THROMBOSIS AND HAEMOSTASIS, 1995, 73 (06) : 1277 - 1277
[7] Antibodies to beta(2)-glycoprotein I - A specific marker for the antiphospholipid syndrome
Guerin, J
Feighery, C
Sim, RB
Jackson, J
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1997, 109 (02): : 304 - 309
[8] beta(2)-glycoprotein I and antiphospholipid syndrome
Koike, T
Matsuura, E
ISRAEL JOURNAL OF MEDICAL SCIENCES, 1997, 33 (04): : 225 - 238
[9] The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome
Brusch, Anna
ANTIBODIES, 2016, 5 (02)
[10] THE BETA-2-GLYCOPROTEIN-I AND ANTIPHOSPHOLIPID ANTIBODIES
SHOENFELD, Y
MERONI, PL
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 1992, 10 (02) : 205 - 209

← 1 2 3 4 5 →