Anion selective chromogenic and fluorogenic chemosensor and its application in breast cancer live cell imaging

被引：34

作者：

Sharma, Darshna ^{[1
]}

Moirangthem, Anuradha ^{[2
]}

Sahoo, Suban K. ^{[1
]}

Basu, Anupam ^{[2
]}

Roy, Sutapa M. ^{[1
]}

Pati, Ranjan K. ^{[1
]}

Kumar, Ashok S. K. ^{[3
]}

Nandre, Jitendra P. ^{[4
]}

Patil, Umesh D. ^{[4
]}

机构：

[1] SV Natl Inst Technol, Dept Appl Chem, Surat, Gujarat, India

[2] Univ Burdwan, Dept Zool, Mol Biol & Human Genet Lab, Burdwan 713104, W Bengal, India

[3] VIT Univ, Sch Adv Sci, Vellore, Tamil Nadu, India

[4] North Maharashtra Univ, Sch Chem Sci, Jalgaon, MS, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 78期

关键词：

FLUORESCENT SENSORS; POTENTIAL APPLICATIONS; AQUEOUS-MEDIA; FLUORIDE; RECOGNITION; COORDINATION; LUMINESCENT; PHOTOPHYSICS; RECEPTOR; ACETATE;

D O I：

10.1039/c4ra04453c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Schiff base receptor (L) bearing catechol and phenol groups was synthesized and characterized by various spectral (FTIR, H-1 NMR and mass) data. The anion recognition ability of L was investigated by experimental (UV-Vis, fluorescence and H-1 NMR) and theoretical (B3LYP/6-31G**) methods. Among the tested anions, the receptor L showed both naked-eye detectable color change from light-yellow to intense brownish-yellow and spectral (hyperchromic shift at 450 nm and 'turn-on' fluorescence at 480 nm) changes selectively towards F- and AcO- in DMSO and mixed DMSO-H2O medium because of the formation of a hydrogen bonded anion-receptor complex followed by the deprotonation of L. The receptor L was tested for live breast cancer cell imaging and can be applied to the breast tumour diagnosis.

引用

页码：41446 / 41452

页数：7

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