Familial aggregation of IgAD and autoimmunity

被引：37

作者：

Jorgensen, Gudmundur H. ^{[1
,2
]}

Thorsteinsdottir, Ingunn ^{[3
]}

Gudmundsson, Sveinn ^{[4
]}

Hammarstrom, Lennart ^{[5
]}

Ludviksson, Bjorn R. ^{[1
,2
]}

机构：

[1] Landspitali Univ Hosp, Dept Immunol, IS-101 Reykjavik, Iceland

[2] Univ Iceland, Dept Med, Reykjavik, Iceland

[3] Landspitali Univ Hosp, Dept Biochem, IS-101 Reykjavik, Iceland

[4] Iceland Blood Bank, Reykjavik, Iceland

[5] Karolinska Univ Hosp, Div Clin Immunol, Huddinge, Sweden

来源：

CLINICAL IMMUNOLOGY | 2009年 / 131卷 / 02期

关键词：

Immunoglobulin A deficiency; Genealogy; IgAD; Autoimmunity; Autoimmune diseases; COMMON VARIABLE IMMUNODEFICIENCY; CIRCULATING IMMUNE-COMPLEXES; DEFICIENT BLOOD-DONORS; DIABETES-MELLITUS; DISEASES; SUSCEPTIBILITY; ANTIBODIES; AUTOANTIBODIES; EPIDEMIOLOGY; ASSOCIATION;

D O I：

10.1016/j.clim.2008.11.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families. Objective: To evaluate the prevalence of autoimmunity among IgAD individuals and their 1 degrees relatives. Material and methods: A total of 43 IgAD individuals (32 adults and 11 children) and all. available 1 degrees relatives were evaluated by a physician. A family history of autoimmunity was obtained, together with physical examination and a structured questionnaire that focused on symptoms and signs suggestive of autoimmunity. Results: Eight of the 32 (25%) adult IgAD, were found to have definite autoimmunity, with organ specific- and systemic autoimmune diseases equally distributed. None of the IgAD children had autoimmunity. Among the 1 degrees relatives, 27/269 (10%) had autoimmunity, compared to an estimate of 5% in the general population (p<0.05). Conclusion: Autoimmune diseases are highly prevalent in individuals with IgAD and more common in their 1 degrees relatives than expected, thus, suggesting a possible common genetic component. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：233 / 239

页数：7

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