Endothelial apoptosis - Could it have a role in the pathogenesis and treatment of disease?

被引：141
作者：
Stefanec, T [1 ]
机构：
[1] St Vincent Hosp & Med Ctr, Sect Crit Care Med, New York, NY USA
来源：
CHEST | 2000年 / 117卷 / 03期
关键词：
apoptosis; atherosclerosis; endothelium; heart failure; hypertension; primary pulmonary hypertension; sepsis;
D O I：
10.1378/chest.117.3.841
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Endothelial apoptosis can be found in a number of diseases. This review summarizes the current knowledge about the causes and consequences of endothelial apoptosis, and analyzes its possible role in the pathogenesis and treatment of several diseases. Novel forms of therapy based on the proposed pathophysiologic mechanisms are discussed.
引用
收藏
页码：841 / 854
页数：14
相关论文
共 178 条
[1]   17 beta-estradiol inhibits apoptosis of endothelial cells [J].
Alvarez, RJ ;
Gips, SJ ;
Moldovan, N ;
Wilhide, CC ;
Milliken, EE ;
Hoang, AT ;
Hruban, RH ;
Silverman, HS ;
Dang, CV ;
GoldschmidtClermont, PJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (02) :372-381
[2]  
ANDERSON JV, 1988, BRIT HEART J, V59, P207
[3]   Levels of circulating adhesion molecules in congestive heart failure and after heart transplantation [J].
Andreassen, AK ;
Nordoy, I ;
Simonsen, S ;
Ueland, T ;
Müller, F ;
Froland, SS ;
Gullestad, L ;
Aukrust, P .
AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (05) :604-608
[4]   FLOW PATTERNS AND SPATIAL-DISTRIBUTION OF ATHEROSCLEROTIC LESIONS IN HUMAN CORONARY-ARTERIES [J].
ASAKURA, T ;
KARINO, T .
CIRCULATION RESEARCH, 1990, 66 (04) :1045-1066
[5]   MICROVASCULAR FUNCTION AND RHEOLOGICAL CHANGES IN HYPERDYNAMIC SEPSIS [J].
ASTIZ, ME ;
DEGENT, GE ;
LIN, RY ;
RACKOW, EC .
CRITICAL CARE MEDICINE, 1995, 23 (02) :265-271
[6]   Elevated circulating levels of C-C chemokines in patients with congestive heart failure [J].
Aukrust, P ;
Ueland, T ;
Müller, F ;
Andreassen, AK ;
Nordoy, I ;
Aas, H ;
Kjekshus, J ;
Simonsen, S ;
Froland, SS ;
Gullestad, L .
CIRCULATION, 1998, 97 (12) :1136-1143
[7]   Endothelin-1 and blood pressure after inhibition of nitric oxide synthesis in human septic shock [J].
Avontuur, JAM ;
Boomsma, F ;
van den Meiracker, AH ;
de Jong, FH ;
Bruining, HA .
CIRCULATION, 1999, 99 (02) :271-275
[8]   Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins [J].
Bannerman, DD ;
Sathyamoorthy, M ;
Goldblum, SE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (52) :35371-35380
[9]   IMMUNOCYTOCHEMICAL DETECTION OF PROGESTERONE RECEPTORS - A STUDY IN A PATIENT WITH PRIMARY PULMONARY-HYPERTENSION [J].
BARBERIS, MCP ;
VERONESE, S ;
BAUER, D ;
DEJULI, E ;
HARARI, S .
CHEST, 1995, 107 (03) :869-872
[10]   Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].
Barnes, PJ ;
Larin, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1066-1071
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