Synthesis of dihalo bi- and terpyridines by regioselective Suzuki-Miyaura cross-coupling reactions

被引：27
作者：
Burzicki, Gregory [1 ]
Voisin-Chiret, Anne Sophie [1 ]
Santos, Jana Soplova-de Oliveira [1 ]
Rault, Sylvain [1 ]
机构：
[1] Univ Caen Basse Normandie, UFR Sci Pharmaceut, Ctr Etudes & Rech Medicament Normandie, UPRES EA 4258,FR CNRS INC3M, F-14032 Caen, France
来源：
TETRAHEDRON | 2009年 / 65卷 / 27期
关键词：
HALOPYRIDINYLBORONIC ACIDS; ESTERS; DERIVATIVES; EFFICIENT; 2,2'/6',2''-TERPYRIDINES; BIPYRIDINE; PYRIDINES; ROUTE;
D O I：
10.1016/j.tet.2009.04.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper describes ail efficient and regioselective synthetic route leading to new dihalobi- and terpyridines. We developed a strategy based on regioselective sequence of Suzuki-Miyaura cross-coupling reactions between bromopyridyl boronic acids and dihalopyridines and dihalobipyridines. The study of the influence of the nature and the position of the halogen atoms leads to prepare bromoiododerivatives to obtain good selectivities. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5413 / 5417
页数：5
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