The Role of Liquid Biopsies in Pediatric Brain Tumors

被引:17
作者
Tang, Karen [1 ,2 ]
Gardner, Sharon [1 ]
Snuderl, Matija [3 ]
机构
[1] New York Univ Langone Hlth, Dept Pediat, Div Hematol Oncol, New York, NY 10016 USA
[2] New York Univ Langone Hlth, Clin & Translat Sci Inst, New York, NY 10016 USA
[3] New York Univ Langone Hlth, Dept Neuropathol, New York, NY 10016 USA
关键词
Central nervous system tumors; Circulating tumor cells; Circulating tumor DNA; Circulating microRNA; Extracellular vesicles; Liquid biopsy; Pediatric brain tumors; CEREBROSPINAL-FLUID CYTOLOGY; GROWTH-FACTOR; MEDULLOBLASTOMA; SYSTEM; CSF; SERUM; DNA; DISSEMINATION; BIOMARKERS; MICRORNAS;
D O I
10.1093/jnen/nlaa068
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Early detection and serial therapeutic monitoring for pediatric brain tumors are essential for diagnosis and therapeutic intervention. Currently, neuropathological diagnosis relies on biopsy of tumor tissue and surgical intervention. There is a great clinical need for less invasive methods to molecularly characterize the tumor and allow for more reliable monitoring of patients during treatment and to identify patients that might potentially benefit from targeted therapies, particularly in the setting where diagnostic tissue cannot be safely obtained. In this literature review, we highlight recent studies that describe the use of circulating tumor DNA, circulating tumor cells, circulating RNA and microRNA, and extracellular vesicles as strategies to develop liquid biopsies in pediatric central nervous system tumors. Liquid biomarkers have been demonstrated using plasma, urine, and cerebrospinal fluid. The use of liquid biopsies to help guide diagnosis, determine treatment response, and analyze mechanisms of treatment resistance is foreseeable in the future. Continued efforts to improve signal detection and standardize liquid biopsy procedures are needed for clinical application.
引用
收藏
页码:934 / 940
页数:7
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