Exploring the Link between Vacuolar-Type Proton ATPase and Epithelial Cell Polarity

被引:0
作者
Sun-Wada, Ge-Hong [1 ]
Wada, Yoh [2 ]
机构
[1] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Kyotanabe, Kyoto 6100395, Japan
[2] Osaka Univ, Inst Sci & Ind Res, Div Biol Sci, 8-1 Mihogaoka, Ibaraki, Osaka 5670047, Japan
关键词
cell polarity; organelle acidification; vacuolar-type H plus -ATPase; epithelial cell; vesicle trafficking; APICAL PLASMA-MEMBRANE; CANINE KIDNEY-CELLS; H+-ATPASE; V-ATPASE; E-CADHERIN; TRANSPORT; LOCALIZATION; TRAFFICKING; LYSOSOMES; ENDOSOMES;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Vacuolar-type H+-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intracellular organelles. Subsequently, it was observed that the proton pump also participates in the acidification of extracellular compartments. V-ATPase plays important roles in a wide range of cell biological processes and physiological functions by generating an acidic pH; therefore, it has attracted much attention not only in basic research but also in pathological and clinical aspects. Emerging evidence indicates that the luminal acidic endocytic organelles and their trafficking may function as important hubs that con-nect and coordinate various signaling pathways. Various pharmacological analyses have suggested that acidic endocytic organelles are important for the maintenance of cell polarity. Recently, several studies using ge-netic approaches have revealed the involvement of V-ATPase in the establishment and maintenance of apico-basal polarity. This review provides a brief overview of the relationship between the polarity of epithelial cells and V-ATPase as well as V-ATPase driven luminal acidification.
引用
收藏
页码:1419 / 1425
页数:7
相关论文
共 50 条
[41]   Sorting of the Yeast Vacuolar-type, Proton-translocating ATPase Enzyme Complex (V-ATPase) IDENTIFICATION OF A NECESSARY AND SUFFICIENT GOLGI/ENDOSOMAL RETENTION SIGNAL IN Stv1p [J].
Finnigan, Gregory C. ;
Cronan, Glen E. ;
Park, Hae J. ;
Srinivasan, Sankaranarayanan ;
Quiocho, Florante A. ;
Stevens, Tom H. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (23) :19487-19500
[42]   Design and Synthesis of 24-Fluorinated Bafilomycin Analogue as an NMR Probe with Potent Inhibitory Activity to Vacuolar-type ATPase [J].
Shibata, Hajime ;
Tsuchikawa, Hiroshi ;
Matsumori, Nobuaki ;
Murata, Michio ;
Usui, Takeo .
CHEMISTRY LETTERS, 2014, 43 (04) :474-476
[43]   Distribution and serotonin-induced activation of vacuolar-type H+-ATPase in the salivary glands of the blowfly Calliphora vicina [J].
Zimmermann, B ;
Dames, P ;
Walz, B ;
Baumann, O .
JOURNAL OF EXPERIMENTAL BIOLOGY, 2003, 206 (11) :1867-1876
[44]   DICYCLOHEXYLCARBODIIMIDE REACTS SPECIFICALLY WITH THE 16KDA SUBUNIT OF LARVAL MANDUCA-SEXTA MIDGUT VACUOLAR-TYPE ATPASE [J].
ZHENG, XY ;
SPAETH, DD ;
HARVEY, WR ;
WOLFERSBERGER, MG .
JOURNAL OF EXPERIMENTAL BIOLOGY, 1992, 165 :273-278
[45]   Structural and Comparative Analyses of Insects Suggest the Presence of an Ultra-Conserved Regulatory Element of the Genes Encoding Vacuolar-Type ATPase Subunits and Assembly Factors [J].
Lovero, Domenica ;
Porcelli, Damiano ;
Giordano, Luca ;
Giudice, Claudio Lo ;
Picardi, Ernesto ;
Pesole, Graziano ;
Pignataro, Eugenia ;
Palazzo, Antonio ;
Marsano, Rene Massimiliano .
BIOLOGY-BASEL, 2023, 12 (08)
[46]   Bafilomycin analogue site-specifically fluorinated at the pharmacophore macrolactone ring has potent vacuolar-type ATPase inhibitory activity [J].
Tsuchikawa, Hiroshi ;
Hayashi, Tatsuru ;
Shibata, Hajime ;
Murata, Michio ;
Nagumo, Yoko ;
Usui, Takeo .
TETRAHEDRON LETTERS, 2016, 57 (22) :2426-2429
[47]   5'-PARA-FLUOROSULFONYLBENZOYLADENOSINE BINDS TO THE 28 KDA SUBUNIT OF LARVAL MANDUCA-SEXTA MIDGUT VACUOLAR-TYPE ATPASE [J].
ZHENG, XY ;
SPAETH, DD ;
HARVEY, WR ;
WOLFERSBERGER, MG .
JOURNAL OF EXPERIMENTAL BIOLOGY, 1992, 164 :301-305
[48]   Inhibition of silkworm vacuolar-type ATPase activity by its inhibitor Bafilomycin A1 induces caspase-dependent apoptosis in an embryonic cell line of silkworm [J].
Tan, Xiao-Yin ;
Wang, Xin ;
Liu, Qing-Song ;
Xie, Xiao-Qian ;
Li, Yi ;
Li, Bing-Qian ;
Li, Zhi-Qing ;
Xia, Qing-You ;
Zhao, Ping .
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 2018, 99 (03)
[49]   Cell Polarity: A Link to Epithelial-Mesenchymal Transition and Vascular Mimicry [J].
Bhattacharya, Susinjan .
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2018, 28 (02) :101-105
[50]   Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes [J].
Kissing, Sandra ;
Rudnik, Soenke ;
Damme, Markus ;
Luellmann-Rauch, Renate ;
Ichihara, Atsuhiro ;
Kornak, Uwe ;
Eskelinen, Eeva-Liisa ;
Jabs, Sabrina ;
Heeren, Joerg ;
De Brabander, Jef K. ;
Haas, Albert ;
Saftig, Paul .
AUTOPHAGY, 2017, 13 (04) :670-685