Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubliquitination and proteasomal degradation

被引：35

作者：

Wakabayashi-Nakao, Kanako ^{[1
]}

Tamura, Ai ^{[1
]}

Furukawa, Tomoka ^{[1
]}

Nakagawa, Hiroshi ^{[1
]}

Ishikawa, Toshihisa ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2009年 / 61卷 / 01期

关键词：

ERAD; Ubiquitin; Proteasome; Endosome; Lysosome; N-glycosylation; Disulfide bond; CANCER RESISTANCE PROTEIN; SINGLE-NUCLEOTIDE POLYMORPHISMS; CASSETTE TRANSPORTER ABCG2; ER-ASSOCIATED DEGRADATION; N-LINKED GLYCOSYLATION; MEMBRANE LOCALIZATION; PLASMA-MEMBRANE; CYSTIC-FIBROSIS; EXPRESSION; GENE;

D O I：

10.1016/j.addr.2008.08.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is a plasma membrane protein carrying intra- and inter-molecular disulfide bonds and an Winked glycan. Both disulfide bond formation and N-glycosylation are critical check points determining the stability and degradation fate of ABCG2 protein in the endoplasmic reticulum (ER). Misfolded ABCG2 protein without those post-translational modifications is removed from the ER by retrotranslocation to the cytosol compartment, ubiquitination by ubiquitin ligase, and finally degradation by proteasomes. Certain non-synonymous SNP variants of ABCG2 undergo such ER-associated degradation (ERAD). (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：66 / 72

页数：7

共 55 条

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