Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

被引：0

作者：

Kizu, J

Arakawa, M

Arakawa, Y

Komoda, F

Takamizawa, M

Iwata, T

Hayakawa, T

Imai, K

机构：

[1] Univ Tokyo, Fac Med, Branch Hosp, Dept Pharm,Bunkyo Ku, Tokyo 1128688, Japan

[2] Univ Tokyo, Fac Med, Branch Hosp, Dept Pediat,Bunkyo Ku, Tokyo 1128688, Japan

[3] Natl Sagamihara Hosp, Ctr Rheumatoallergol, Dept Res, Sagamihara, Kanagawa 2280815, Japan

[4] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Bioanalyt Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BIOMEDICAL CHROMATOGRAPHY | 1999年 / 13卷 / 07期

关键词：

D O I：

10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy. Copyright (C) 1999 John Wiley & Sons, Ltd.

引用

页码：462 / 464

页数：3

共 7 条

[1] MONITORING SERUM THEOPHYLLINE LEVELS
HENDELES, L
WEINBERGER, M
JOHNSON, G
[J]. CLINICAL PHARMACOKINETICS, 1978, 3 (04) : 294 - 312
[2] Kizu J, 1999, BIOMED CHROMATOGR, V13, P15, DOI 10.1002/(SICI)1099-0801(199902)13:1<15::AID-BMC766>3.3.CO
[3] 2-4
[4] Masaki T, 1981, Arerugi, V30, P190
[5] RIEM HH, 1995, BR J CLIN PHARM, V39, P321
[6] TANGLIU DD, 1983, J PHARMACOL EXP THER, V224, P180
[7] THEOPHYLLINE METABOLISM IN PREMATURE-INFANTS
TSERNG, KY
KING, KC
TAKIEDDINE, FN
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 29 (05) : 594 - 600

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