C-Glucosylflavonoid biosynthesis from 2-hydroxynaringenin by Desmodium uncinatum (Jacq.) (Fabaceae)

被引：18
作者：
Hamilton, Mary L. [1 ]
Caulfield, John C. [1 ]
Pickett, John A. [1 ]
Hooper, Antony M. [1 ]
机构：
[1] Rothamsted Res, Dept Biol Chem, Ctr Sustainable Pest & Dis Management, Harpenden AL5 2JQ, Herts, England
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 40期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Desmodium uncinatum; C-Glycosyltransferase; Biosynthesis; C-Glycosylflavonoid; 2-Hydroxynaringenin; Vitexin; Isovitexin; Deuterium labelling; STRIGA-HERMONTHICA; SPP; GLYCOSYLATION; FLAVONOIDS; INTERCROPS; CEREALS; MAIZE; WEEDS;
D O I：
10.1016/j.tetlet.2009.07.118
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[2',3',5',6'-H-2(4)]-2-Hydroxynaringenin is synthesised and incubated with commercially available UDP-glucose and the crude protein extract from Desmoduim uncinatum leaves. The organic extract produces isotopically labelled [2',3',5',6'-H-2(4)]-vitexin and [2',3',5',6'-H-2(4)]-isovitexin. Repeating the experiment with denatured protein or replacing the 2-hydroxynaringenin with [2',3',5',6'-H-2(4)]-apigenin or [2',3',5',6'-H-2(4)]- naringenin results in no observable incorporation. 2-Hydroxynaringenin is therefore the substrate for C-glucosylflavonoid biosynthesis in D. uncinatum. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5656 / 5659
页数：4
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