Effect of probiotics and gut microbiota on anti-cancer drugs: Mechanistic perspectives

被引:139
作者
Badgeley, Aja [1 ]
Anwar, Hina [1 ]
Modi, Karan [1 ]
Murphy, Paige [1 ]
Lakshmikuttyamma, Ashakumary [1 ]
机构
[1] Thomas Jefferson Univ, Jefferson Coll Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19107 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 01期
关键词
Probiotics; Gut microbiota; Lactobacillus; Bifidobacterium; cancer prevention; LACTOBACILLUS-RHAMNOSUS GG; RANDOMIZED DOUBLE-BLIND; BREAST-CANCER; FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; COLON-CANCER; INTESTINAL MICROBIOTA; INDUCED DIARRHEA; CHECKPOINT-BLOCKADE; FECAL MICROBIOTA;
D O I
10.1016/j.bbcan.2020.188494
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bacteria present in probiotics, particularly the common Lactobacillus and Bifidobacterium microbes, have been found to induce anti-cancer action by enhancing cancer cell apoptosis and protecting against oxidative stress. Probiotics supplements also decrease the cancer-producing microorganism Fusobacterium. Studies have demonstrated that gut microbiota modifies the effect of chemo/radiation therapy. Gut microbes not only enhance the action of chemotherapy drugs but also reduce the side effects of these medications. Additionally, gut microbes reduce immunotherapy toxicity, in particular, the presence of Bacteroidetes or Bifidobacterium decreases the development of colitis by ipilimumab therapy. Probiotics supplements containing Bifidobacterium also reduce chemotherapy-induced mucositis and radiation-induced diarrhea. This review focused on elucidating the mechanism behind the anti-cancer action of Bifidobacterium species. Available studies have revealed Bifidobacterium species decrease cancer cell proliferation via the inhibition of growth factor signaling as well as inducing mitochondrial-mediated apoptosis. Moreover, Bifidobacterium species reduce the adverse effects of chemo/immuno/radiation therapy by inhibiting proinflammatory cytokines. Further clinical studies are needed to identify the powerful and suitable Bifidobacterium strain for the development of adjuvant therapy to support chemo/immuno/radiation therapy.
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页数:13
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