Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector

被引：58

作者：

Wang, Yating ^{[1
,2
]}

Xu, Dong ^{[1
,2
]}

Yang, Sihua ^{[1
,2
]}

Xing, Da ^{[1
,2
]}

机构：

[1] S China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

[2] S China Normal Univ, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 02期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

PIGMENTED SKIN-LESIONS; CUTANEOUS MELANOMA; MICROSCOPY; MANAGEMENT; TOMOGRAPHY; RESECTION;

D O I：

10.1364/BOE.7.000279

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanoma is the most dangerous type of skin cancer with high lethal rate. Tumor thickness and tumor-associated vasculature are two key parameters for staging melanoma. Previous techniques for diagnosing melanoma have insurmountable restrictions, such as invasive, low specificity, or inaccurate depth measurement. Here we develop an integrated photoacoustic (PA) and ultrasound (US) imaging system dedicated to overcome these limitations. An integrated detector with sound-light coaxial/confocal design and flexible coupling mode is employed for the combined PA/US imaging strategy. PA imaging results enable a clear characterization of tumor angiogenesis with high resolution and high contrast. Furthermore, accurate thickness measurements of melanoma in different stages can be resolved with the simultaneously obtained PA/US image. Phantom experiments and in vivo animal experimental results demonstrate the integrated PA/US system could provide potential for noninvasive biopsy of melanoma. (C) 2016 Optical Society of America

引用

页码：279 / 286

页数：8

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