Solubility study of acetaminophen in the mixtures of acetonitrile and water at different temperatures

被引：14
作者：
Rahimpour, Elaheh [1 ,2 ,3 ]
Agha, Elnaz Mazaher Haji [4 ]
Martinez, Fleming [5 ]
Barzegar-Jalali, Mohammad [6 ,7 ]
Jouyban, Abolghasem [1 ,2 ,8 ]
机构：
[1] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[5] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim, Cra 30 45-03, Bogota, DC, Colombia
[6] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[7] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran
[8] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz, Iran
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 324卷
关键词：
Solubility; Paracetamol; Acetonitrile; Binary solvent mixtures; Cosolvency models; Dissolution thermodynamics; Preferential solvation; ENTHALPY-ENTROPY COMPENSATION; PREFERENTIAL SOLVATION; SOLUTION THERMODYNAMICS; DRUG DISCOVERY; PARACETAMOL; ACETANILIDE; DEPENDENCE; MODELS; ACID;
D O I：
10.1016/j.molliq.2020.114708
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Acetaminophen solubility in the mixtures of acetonitrile and water in the temperature range of 293.2-313.2 K is determined by a shake-flaskmethod followed by spectrophotometry method. The generated data are correlated with some linear and non-linear solubility models. Furthermore, the density of saturated mixtures at different temperatures is also regressed by the Jouyban-Acree model. The accuracy of each used model is investigated by the mean relative deviations (MRD%) of the back-calculated solubility or density data. The apparent thermodynamic properties of acetaminophen dissolution, mixing and solvation in the mixtures of acetonitrile and water are also computed based on the van't Hoff and Gibbs equations. Furthermore, based on the inverse Kirkwood-Buff integrals the preferential solvation parameters of acetaminophen by acetonitrile were also calculated. (C) 2020 Elsevier B.V. All rights reserved.
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页数：9
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