Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells

被引:3
作者
Misra, Asish C. [1 ,7 ]
Park, Toe-Hong [2 ,8 ]
Carney, Randy P. [4 ,5 ]
Rusciano, Giulia [6 ]
Stellacci, Francesco [4 ,5 ]
Lahann, Joerg [1 ,2 ,3 ]
机构
[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
[3] Karlsruhe Inst Technol, Inst Funct Interfaces, D-76131 Karlsruhe, Germany
[4] Ecole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland
[5] Ecole Polytech Fed Lausanne, Interfac Inst Bioengn, CH-1015 Lausanne, Switzerland
[6] Univ Napoli Federico II, Dipartimento Fis Ettore Pancini, I-80138 Naples, NA, Italy
[7] Beth Israel Deaconess Med Ctr, Dept Surg, 330 Brookline Ave, Boston, MA 02215 USA
[8] Korea Atom Energy Res Inst, 111 Daedeok Daero 989beon Gil, Daejeon, South Korea
关键词
nanoparticles; plasma membranes; subcellular targeting; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; BIPHASIC NANOCOLLOIDS; GOLD NANOPARTICLES; JANUS PARTICLES; POTENTIAL USE; SHAPE; PENETRATION; ANISOTROPY; CLUSTERS;
D O I
10.1002/smtd.201800408
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self-assembly. Here, hierarchical assemblies of fully synthetic particles that selectively localize to the plasma membrane of mammalian cells are presented. A multimodal approach is used to create assemblies of polymer-based carrier particles with amphiphilic gold nanoparticles immobilized on one hemisphere. These assemblies persist in the plasma membrane of cells for several days and undergo rearrangements and clustering, typically considered to be hallmarks of membrane-bound receptors.
引用
收藏
页数:9
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