Breast cancer banishes p27 from nucleus

被引：88

作者：

Blain, SW ^{[1
]}

Massagué, J

机构：

[1] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA

[2] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[3] Howard Hughes Med Inst, New York, NY USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 10期

关键词：

D O I：

10.1038/nm1002-1076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell-cycle inhibitor p27 is phosphorylated by the Akt kinase in breast cancer, according to three new studies. This phosphorylation keeps p27 in the cytoplasm and correlates with cancer aggressiveness (pages 1136-1144, 1145-1152 and 1153-1160).

引用

页码：1076 / 1078

页数：4

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