Glucose, glycolysis and lymphocyte responses

被引：131
作者：
Donnelly, Raymond P.
Finlay, David K. [1 ]
机构：
[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland
来源：
MOLECULAR IMMUNOLOGY | 2015年 / 68卷 / 02期
基金：
爱尔兰科学基金会;
关键词：
Glycolysis; Metabolism; Lymphocyte; Natural Killer cell; T cell; B cell; mTORC1; c-Myc; HIF1-alpha; Oxidative phosphorylation; Glucose; Galactose; IFN gamma; Granzyme B; GAPDH; review; CD8(+) T-CELLS; RAPAMYCIN COMPLEX 1; EFFECTOR FUNCTION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; AEROBIC GLYCOLYSIS; METABOLIC PATHWAYS; B-LYMPHOCYTES; CUTTING EDGE; C-MYC; MEMORY;
D O I：
10.1016/j.molimm.2015.07.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activated lymphocytes engage in robust growth and rapid proliferation. To achieve this, they tend to adopt a form of glucose metabolism termed aerobic glycolysis. This type of metabolism allows for the use of large amounts of glucose to generate energy, but also to support biosynthetic processes. This review article will discuss how aerobic glycolysis supports the biosynthetic demands of activated T cells, B cells and Natural Killer cells, and the emerging concept that glycolysis is integrally linked to the differentiation and function of these lymphocyte populations. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：513 / 519
页数：7
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