The role of IL-18 in innate immunity

被引：314
作者：
Akira, S [1 ]
机构：
[1] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, CREST Japan Sci & Technol Corp, Suita, Osaka 5650871, Japan
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(99)00051-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response.
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页码：59 / 63
页数：5
相关论文
共 35 条
[1]   Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].
Adachi, O ;
Kawai, T ;
Takeda, K ;
Matsumoto, M ;
Tsutsui, H ;
Sakagami, M ;
Nakanishi, K ;
Akira, S .
IMMUNITY, 1998, 9 (01) :143-150
[2]  
Ahn HJ, 1997, J IMMUNOL, V159, P2125
[3]  
Barbulescu K, 1998, J IMMUNOL, V160, P3642
[4]   A newly defined interleukin-1? [J].
Bazan, JF ;
Timans, JC ;
Kastelein, RA .
NATURE, 1996, 379 (6566) :591-591
[5]   Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling [J].
Born, TL ;
Thomassen, E ;
Bird, TA ;
Sims, JE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) :29445-29450
[6]   Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon γ production from CD4+ versus CD8+ T cells [J].
Carter, LL ;
Murphy, KM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (08) :1355-1360
[7]   Overview of interleukin-18:: more than an interferon-γ inducing factor [J].
Dinarello, CA ;
Novick, D ;
Puren, AJ ;
Fantuzzi, G ;
Shapiro, L ;
Mühl, H ;
Yoon, DY ;
Reznikov, LL ;
Kim, SH ;
Rubinstein, M .
JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 63 (06) :658-664
[8]   Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production [J].
Ghayur, T ;
Banerjee, S ;
Hugunin, M ;
Butler, D ;
Herzog, L ;
Carter, A ;
Quintal, L ;
Sekut, L ;
Talanian, R ;
Paskind, M ;
Wong, W ;
Kamen, R ;
Tracey, D ;
Allen, H .
NATURE, 1997, 386 (6625) :619-623
[9]   Activation of interferon-gamma inducing factor mediated by interleukin-1 beta converting enzyme [J].
Gu, Y ;
Kuida, K ;
Tsutsui, H ;
Ku, G ;
Hsiao, K ;
Fleming, MA ;
Hayashi, N ;
Higashino, K ;
Okamura, H ;
Nakanishi, K ;
Kurimoto, M ;
Tanimoto, T ;
Flavell, RA ;
Sato, V ;
Harding, MW ;
Livingston, DJ ;
Su, MSS .
SCIENCE, 1997, 275 (5297) :206-209
[10]  
Hofstra CL, 1998, J IMMUNOL, V161, P5054
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