TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease

被引：15

作者：

Culpan, Doris ^{[1
]}

Cram, Dougal ^{[1
]}

Chalmers, Kate ^{[1
]}

Cornish, Abigail ^{[1
]}

Palmer, Laura ^{[1
]}

Palmer, Jennifer ^{[1
]}

Hughes, Anthony ^{[1
]}

Passmore, Peter ^{[2
]}

Craigs, David ^{[2
]}

Wilcock, Gordon K. ^{[1
]}

Kehoe, Patrick G. ^{[1
]}

Love, Seth ^{[1
]}

机构：

[1] Univ Bristol, Frenchay Hosp, Dept Clin Sci N Bristol, Inst Clin Neurosci,Dementia Res Grp, Bristol BS16 1LE, Avon, England

[2] Queens Univ, Dept Geriatr Med, Belfast BT9 7BL, Antrim, North Ireland

来源：

NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 07期

关键词：

Alzheimers' disease; Inflammation; TNF-alpha; TRAF-2; signaling; Immunohistochemistry; Genetics; mRNA; RECEPTOR-ASSOCIATED FACTOR-2; MESSENGER-RNA; ADAPTER PROTEINS; KAPPA-B; ACTIVATION; STRESS; DEGRADATION; FAMILY; EXPRESSION; LIFE;

D O I：

10.1016/j.neurobiolaging.2007.10.014

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Levels of tumor necrosis factor-alpha (TNF-alpha) are increased in the brain in Alzheimer's disease (AD). The TNF-alpha/TNF-R signaling pathways involve complex interactions between several proteins, including TNF-receptor-associated factor-2 (TRAF-2). We have examined the distribution and levels of TRAF-2 in AD and control brains and also whether single nucleofide potymorphisms (SNPs) in the TRAF-2 gene are associated with AD and influence TRAF-2 expression. Immitmohistochemistry demonstrated TRAF-2 in AD and control cortex in neurons, within plaque-associated neurites and some neurofibrillary tangles. Western blots revealed a band of the expected apparent molecular mass (similar to 50 kDa) for TRAF-2, in homogenates of AD and control cortex. RT-PCR showed the levels of TRAF-2 mRNA to be significantly higher in the frontal cortex of AD than control brains (p = 0.015). TRAF-2 mRNA expression was not linked to any SNPs. The 3' UTR SNP (rs7852970) GG allele was significantly protective against AD (p = 0.030). Our findings suggest that the TRAF-2 pathway is involved AD. The mechanisms are currently unclear and need further examination. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：1052 / 1060

页数：9

共 34 条

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