CD19-Targeted CAR T Cells: A New Tool in the Fight against B Cell Malignancies

被引：21

作者：

Miller, Brian C. ^{[1
]}

Maus, Marcela V. ^{[2
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc, Boston, MA USA

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2015年 / 38卷 / 12期

关键词：

CAR T cell; CD19; T cell therapies; Adoptive transfer; B cell; Chimeric antigen receptor; Immunotherapy; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; ADOPTIVE IMMUNOTHERAPY; SUSTAINED REMISSIONS; ADVERSE EVENT; CD19; ANTIGEN; PHASE-I; RECEPTOR; LYMPHOMA; CHEMOTHERAPY;

D O I：

10.1159/000442170

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adoptive cell immunotherapy is a novel tool in the fight against cancer. Serving both effector and memory functions for the immune system, T cells make an obvious candidate for adoptive cell immunotherapy. By modifying native T cells with a chimeric antigen receptor (CAR), these cells can theoretically be targeted against any extracellular antigen. To date, the best-studied and clinically validated CAR T cells recognize CD19, a cell surface molecule on B cells and B cell malignancies. These CD19-directed T cells have shown clinical utility in chronic lymphocytic leukemia, acute lymphoblastic leukemia (ALL), and non-Hodgkin's lymphomas, with some patients achieving long-term disease remissions after treatment. This review will briefly summarize the current data supporting the use of adoptively transferred CAR T cells for the treatment of CD19-positive malignancies. Given these exciting results, the Food and Drug Administration has granted a 'breakthrough' designation for several variations of CD19-directed CAR T cells for treatment of adult and pediatric relapsed/refractory ALL. (C) 2015 S. Karger GmbH, Freiburg

引用

页码：683 / 690

页数：8

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