Impact of a commercially available model-based dose calculation algorithm on treatment planning of high-dose-rate brachytherapy in patients with cervical cancer

被引：17

作者：

Abe, Kota ^{[1
]}

Kadoya, Noriyuki ^{[1
]}

Sato, Shinya ^{[1
]}

Hashimoto, Shimpei ^{[2
]}

Nakajima, Yujiro ^{[1
,2
]}

Miyasaka, Yuya ^{[1
,3
]}

Ito, Kengo ^{[1
]}

Umezawa, Rei ^{[1
]}

Yamamoto, Takaya ^{[1
]}

Takahashi, Noriyoshi ^{[1
]}

Takeda, Ken ^{[4
]}

Jingu, Keiichi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Radiat Oncol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan

[2] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Dept Radiat Oncol, Bunkyo Ku, 3-18-22 Honkomagome, Tokyo 1138677, Japan

[3] Yamagata Univ, Dept Radiat Oncol, Fac Med, 2-2-2 Iidani, Yamagata 9909585, Japan

[4] Tohoku Univ, Grad Sch Med, Dept Therapeut Radiol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan

来源：

JOURNAL OF RADIATION RESEARCH | 2018年 / 59卷 / 02期

基金：

日本学术振兴会;

关键词：

radiotherapy; brachytherapy; model-based dose calculation algorithm; Monte Carlo simulation; cervical cancer; RATE INTRACAVITARY BRACHYTHERAPY; COLLAPSED CONE CONVOLUTION; DOSIMETRY PARAMETERS; TG-43; FORMALISM; RECOMMENDATIONS; RADIOTHERAPY; IR-192; APPLICATOR; PROTOCOL; THERAPY;

D O I：

10.1093/jrr/rrx081

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We evaluated the impact of model-based dose calculation algorithms (MBDCAs) on high-dose-rate brachytherapy (HDR-BT) treatment planning for patients with cervical cancer. Seven patients with cervical cancer treated using HDR-BT were studied. Tandem and ovoid applicators were used in four patients, a vaginal cylinder in one, and interstitial needles in the remaining two patients. MBDCAs were applied to the Advanced Collapsed cone Engine (ACE; Elekta, Stockholm, Sweden). All plans, which were originally calculated using TG-43, were re-calculated using both ACE and Monte Carlo (MC) simulations. Air was used as the rectal material. The mean difference in the rectum D-2cm3 between ACE(rec-air) and MCrec-air was 8.60 +/- 4.64%, whereas that in the bladder D-2cm3 was - 2.80 +/- 1.21%. Conversely, in the small group analysis (n = 4) using water instead of air as the rectal material, the mean difference in the rectum D-2cm3 between TG-43 and ACE(rec-air) was 11.87 +/- 2.65%, whereas that between TG-43 and ACE(rec-water) was 0.81 +/- 2.04%, indicating that the use of water as the rectal material reduced the difference in D-2cm3 between TG-43 and ACE. Our results suggested that the differences in the dose-volume histogram (DVH) parameters of TG-43 and ACE were large for the rectum when considerable air (gas) volume was present in it, and that this difference was reduced when the air (gas) volume was reduced. Also, ACE exhibited better dose calculation accuracy than that of TG-43 in this situation. Thus, ACE may be able to calculate the dose more accurately than TG-43 for HDR-BT in treating cervical cancers, particularly for patients with considerable air (gas) volume in the rectum.

引用

页码：198 / 206

页数：9

共 29 条

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