Autism and Sensory Processing Disorders: Shared White Matter Disruption in Sensory Pathways but Divergent Connectivity in Social-Emotional Pathways

被引:132
作者
Chang, Yi-Shin [1 ]
Owen, Julia P. [1 ]
Desai, Shivani S. [2 ]
Hill, Susanna S. [2 ]
Arnett, Anne B. [2 ]
Harris, Julia [2 ]
Marco, Elysa J. [2 ]
Mukherjee, Pratik [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94115 USA
关键词
INFERIOR LONGITUDINAL FASCICULUS; DIFFUSION TENSOR TRACKING; HIPPOCAMPO-FUSIFORM; AMYGDALO-FUSIFORM; SPECTRUM DISORDER; CORPUS-CALLOSUM; CHILDREN; SYSTEM; FMRI; ABNORMALITIES;
D O I
10.1371/journal.pone.0103038
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Over 90% of children with Autism Spectrum Disorders (ASD) demonstrate atypical sensory behaviors. In fact, hyper- or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment is now included in the DSM-5 diagnostic criteria. However, there are children with sensory processing differences who do not meet an ASD diagnosis but do show atypical sensory behaviors to the same or greater degree as ASD children. We previously demonstrated that children with Sensory Processing Disorders (SPD) have impaired white matter microstructure, and that this white matter microstructural pathology correlates with atypical sensory behavior. In this study, we use diffusion tensor imaging (DTI) fiber tractography to evaluate the structural connectivity of specific white matter tracts in boys with ASD (n = 15) and boys with SPD (n = 16), relative to typically developing children (n = 23). We define white matter tracts using probabilistic streamline tractography and assess the strength of tract connectivity using mean fractional anisotropy. Both the SPD and ASD cohorts demonstrate decreased connectivity relative to controls in parieto-occipital tracts involved in sensory perception and multisensory integration. However, the ASD group alone shows impaired connectivity, relative to controls, in temporal tracts thought to subserve social-emotional processing. In addition to these group difference analyses, we take a dimensional approach to assessing the relationship between white matter connectivity and participant function. These correlational analyses reveal significant associations of white matter connectivity with auditory processing, working memory, social skills, and inattention across our three study groups. These findings help elucidate the roles of specific neural circuits in neurodevelopmental disorders, and begin to explore the dimensional relationship between critical cognitive functions and structural connectivity across affected and unaffected children.
引用
收藏
页数:17
相关论文
共 47 条
[1]   Prevalence of parents' perceptions of sensory processing disorders among kindergarten children [J].
Ahn, RR ;
Miller, LJ ;
Milberger, S ;
McIntosh, DN .
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY, 2004, 58 (03) :287-293
[2]   Diffusion tensor imaging of the corpus callosum in Autism [J].
Alexander, Andrew L. ;
Lee, Jee Eun ;
Lazar, Mariana ;
Boudos, Rebecca ;
DuBray, Molly B. ;
Oakes, Terrence R. ;
Miller, Judith N. ;
Lu, Jeffrey ;
Jeong, Eun-Kee ;
McMahon, William M. ;
Bigler, Erin D. ;
Lainhart, Janet E. .
NEUROIMAGE, 2007, 34 (01) :61-73
[3]  
[Anonymous], 2003, WECHSLER INTELLIGENC
[4]  
[Anonymous], 1994, DSM 4 DIAGNOSTIC STA
[5]   Comparison of white matter integrity between autism spectrum disorder subjects and typically developing individuals: a meta-analysis of diffusion tensor imaging tractography studies [J].
Aoki, Yuta ;
Abe, Osamu ;
Nippashi, Yasumasa ;
Yamasue, Hidenori .
MOLECULAR AUTISM, 2013, 4
[6]   Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? [J].
Behrens, T. E. J. ;
Berg, H. Johansen ;
Jbabdi, S. ;
Rushworth, M. F. S. ;
Woolrich, M. W. .
NEUROIMAGE, 2007, 34 (01) :144-155
[7]   A Meta-Analysis of Sensory Modulation Symptoms in Individuals with Autism Spectrum Disorders [J].
Ben-Sasson, Ayelet ;
Hen, Liat ;
Fluss, Ronen ;
Cermak, Sharon A. ;
Engel-Yeger, Batya ;
Gal, Eynat .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2009, 39 (01) :1-11
[8]   Multisensory integration in children: A preliminary ERP study [J].
Brett-Green, Barbara A. ;
Miller, Lucy J. ;
Gavin, William J. ;
Davies, Patricia L. .
BRAIN RESEARCH, 2008, 1242 :283-290
[9]   How does sensory processing dysfunction affect play? [J].
Bundy, Anita C. ;
Shia, Sue ;
Qi, Long ;
Miller, Lucy Jane .
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY, 2007, 61 (02) :201-208
[10]   Functional connectivity in a baseline resting-state network in autism [J].
Cherkassky, Vladimir L. ;
Kana, Rajesh K. ;
Keller, Timothy A. ;
Just, Marcel Adam .
NEUROREPORT, 2006, 17 (16) :1687-1690