Antimicrobial Activity of Fullerenes and Their Hydroxylated Derivatives

被引：76
作者：
Aoshima, Hisae [1 ]
Kokubo, Ken [2 ]
Shirakawa, Shogo [2 ]
Ito, Masayuki [1 ]
Yamana, Shuichi [1 ]
Oshima, Takumi [2 ]
机构：
[1] Vitamin C60 BioRes Corp, Chuo Ku, Tokyo 1030028, Japan
[2] Osaka Univ, Grad Sch Engn, Div Appl Chem, Suita, Osaka 5650871, Japan
来源：
BIOCONTROL SCIENCE | 2009年 / 14卷 / 02期
关键词：
Fullerenol; Antibacteria; Antifungi; MIC; WATER; C-60; ANTIBACTERIAL;
D O I：
10.4265/bio.14.69
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The antimicrobial activities of fullerene C-60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. The tested samples were water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C-60, gamma-cyclodextrin (gamma-CD)/C-60, and nano-C-60) and 3 types of fullerenols (C-60(OH)(12), C-60(OH)(36) center dot 8H(2)O, and C-60 (OH)(44) center dot 8H(2)O). Their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. Although pristine C-60 demonstrated no antimicrobial activity, fullerenols exhibited good antimicrobial activity against Propionibacterium acnes, Staphylococcus epidermidis, Candida albicans, and Malassezia furfur. In particular, C-60 (OH)(44) exhibited a strong and wide-ranging antimicrobial activity comparable to that of catechin. This compound exhibits antimicrobial activity via inhibition of microbial cell growth and not via bactericidal activity.
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页码：69 / 72
页数：4
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