Antimicrobial Activity of Fullerenes and Their Hydroxylated Derivatives

被引：79

作者：

Aoshima, Hisae ^{[1
]}

Kokubo, Ken ^{[2
]}

Shirakawa, Shogo ^{[2
]}

Ito, Masayuki ^{[1
]}

Yamana, Shuichi ^{[1
]}

Oshima, Takumi ^{[2
]}

机构：

[1] Vitamin C60 BioRes Corp, Chuo Ku, Tokyo 1030028, Japan

[2] Osaka Univ, Grad Sch Engn, Div Appl Chem, Suita, Osaka 5650871, Japan

来源：

BIOCONTROL SCIENCE | 2009年 / 14卷 / 02期

关键词：

Fullerenol; Antibacteria; Antifungi; MIC; WATER; C-60; ANTIBACTERIAL;

D O I：

10.4265/bio.14.69

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The antimicrobial activities of fullerene C-60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. The tested samples were water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C-60, gamma-cyclodextrin (gamma-CD)/C-60, and nano-C-60) and 3 types of fullerenols (C-60(OH)(12), C-60(OH)(36) center dot 8H(2)O, and C-60 (OH)(44) center dot 8H(2)O). Their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. Although pristine C-60 demonstrated no antimicrobial activity, fullerenols exhibited good antimicrobial activity against Propionibacterium acnes, Staphylococcus epidermidis, Candida albicans, and Malassezia furfur. In particular, C-60 (OH)(44) exhibited a strong and wide-ranging antimicrobial activity comparable to that of catechin. This compound exhibits antimicrobial activity via inhibition of microbial cell growth and not via bactericidal activity.

引用

页码：69 / 72

页数：4

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