Fabrication, mechanical properties, and biocompatibility of reduced graphene oxide-reinforced nanofiber mats

被引:44
作者
Jin, Lin [1 ]
Yue, Dan [1 ]
Xu, Zhe-Wu [2 ]
Liang, Guobin [3 ]
Zhang, Yilei [4 ]
Zhang, Jian-Fu [1 ]
Zhang, Xingcai [5 ]
Wang, Zhenling [1 ]
机构
[1] Zhoukou Normal Univ, Key Lab Rare Earth Funct Mat & Applicat, Zhoukou 466001, Peoples R China
[2] Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Hosp Stomatol, Dept Oral & Maxillofacial Surg,Guanghua Sch Stoma, Guangzhou 510055, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Dept Prosthodont, Guangzhou 510055, Guangdong, Peoples R China
[4] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore
[5] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA
来源
RSC ADVANCES | 2014年 / 4卷 / 66期
基金
中国国家自然科学基金;
关键词
FIBROUS SCAFFOLD; COMPOSITE FILMS; SHEETS; DIFFERENTIATION; PERFORMANCE; MEMBRANE; CELLS;
D O I
10.1039/c4ra03987d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Fibrous functional scaffolds that could mimic the natural growth environment of cells and govern cell-specific behaviors are crucial for meeting the requirements of tissue engineering. Graphene-based materials, which is an important one of them have captured tremendous interests of researchers. However, few research about graphene nanofibers with excellent electrical and mechanical properties have been fabricated and found to have real applications. In this study, we reported a novel PAN-reduced graphene oxide reinforced composite nanofiber mats (rGO-NFMs), which were fabricated by the electrospinning process combined with chemical reduction. SEM, FTIR and XRD revealed that rGO-NFMs were successfully produced. These rGO-NFMs displayed superior mechanical properties (tensile strain and tensile stress are 18.5% and 1.38 MPa, respectively). The cell proliferation and morphology of adipose-derived stem cells (ADSCs as model cells) cultured on the rGO-NFMs were tested with a 7 days culture period. Cellular test results showed that rGO-NFMs exhibited excellent biocompatibility, cells on the nanofibers formed stable cell-fiber constructs, and the rate of cell proliferation was similar to that of tissue culture plates (TCPs) and PAN nanofibers mats (PAN-NFMs). This study demonstrated that rGO-NFMs may be a good choice for application in tissue engineering, particularly cell culture scaffolds for electrical stimulation.
引用
收藏
页码:35035 / 35041
页数:7
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