Potent Acetyleholinesterase Inhibitory Compounds from Myristica fragrans

被引：1

作者：

To Dao Cuong ^{[1
,2
]}

Tran Manh Hung ^{[1
]}

Han, Hyoung Yun ^{[3
]}

Roh, Hang Sik ^{[3
]}

Seok, Ji-Hyeon ^{[4
]}

Lee, Jong Kwon ^{[4
]}

Jeong, Ja Young ^{[4
]}

Choi, Jae Sue ^{[5
]}

Kim, Jeong Ah ^{[6
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea

[2] Vietnam Acad Sci & Technol, Inst Nat Prod Chem, Hanoi, Vietnam

[3] Korea Inst Toxicol, Taejon 305343, South Korea

[4] Korea Food Drug Adm, Chungcheongbuk Do 363951, South Korea

[5] Pukyong Natl Univ, Fac Food Sci & Biotechnol, Pusan 608737, South Korea

[6] Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Taegu 702701, South Korea

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Myristica fragrans; Myristicaceae; Lignans; Anti-Alzheimer; Acetylcholinesterase; ALZHEIMERS-DISEASE; CHOLINESTERASE-INHIBITORS; MEMORY IMPAIRMENT; NO PRODUCTION; RISK-FACTORS; LIGNANS; ACETYLCHOLINESTERASE; CONSTITUENTS; PREVALENCE; NEOLIGNANS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-cholinesterase activity was evaluated of the ethyl acetate fraction of the methanol extract of Myristica fragrans Houtt (Myristicaceae) seeds and of compounds isolated from it by various chromatographic techniques. The chemical structures of the compounds were determined from spectroscopic analyses (NMR data). Thirteen compounds (1-13) were isolated and identified. Compound 8 {[(7S)-8'-(4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl]benzene-2,4-diol} showed the most effective activity with an IC50 value of 35.1 mu M, followed by compounds 2 [(8R,8'S)-7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane] and 11 (malabaricone C) with IC50 values of 42.1 and 44.0 mu M, respectively. This is the first report of significant anticholinesterase properties of M. fragrans seeds. The findings demonstrate that M.fragrans could be used beneficially in the treatment of Alzheimer's disease.

引用

页码：499 / 502

页数：4

共 33 条

[21] O-demethylation of meso-dimethyl dihydroguaiaretic acid in Spodoptera litura
Miyazawa, M
Kasahara, H
Kameoka, H
[J]. PHYTOCHEMISTRY, 1997, 46 (07) : 1173 - 1175
[22] Alzheimer's disease pathogenesis and therapeutic interventions
Parihar, MS
Hemnani, T
[J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2004, 11 (05) : 456 - 467
[23] Effect of long-term administration of berberine on scopolamine-induced amnesia in rats
Peng, WH
Hsieh, MT
Wu, CR
[J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1997, 74 (03) : 261 - 266
[24] THE CHOLINERGIC HYPOTHESIS - 10 YEARS ON
PERRY, EK
[J]. BRITISH MEDICAL BULLETIN, 1986, 42 (01) : 63 - 69
[25] Cytotoxic acylphenols from Myristica maingayi
Pham, VC
Jossang, A
Sévenet, T
Bodo, B
[J]. TETRAHEDRON, 2000, 56 (12) : 1707 - 1713
[26] Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease
Rao, Allam A.
Sridhar, Gumpeny R.
Das, Undurti N.
[J]. MEDICAL HYPOTHESES, 2007, 69 (06) : 1272 - 1276
[27] REGIOSELECTIVE CLEAVAGE OF THE METHYLENEDIOXY GROUP - CONVERSION OF (-)-AUSTROBAILIGNAN-5 TO (-)-DIHYDROGUAIARETIC ACID
RAO, KV
CHATTOPADHYAY, SK
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (05) : 1427 - 1429
[28] Treatment of Alzheimer's disease: current status and new perspectives
Scarpini, E
Scheltens, P
Feldman, H
[J]. LANCET NEUROLOGY, 2003, 2 (09) : 539 - 547
[29] Tougu V., 2001, Current Medicinal Chemistry - Central Nervous System Agents, V1, P155, DOI 10.2174/1568015013358536
[30] β-Secretase (BACE) as a drug target for alzheimer's disease
Vassar, R
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (12) : 1589 - 1602

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