Continuous particle separation through deterministic lateral displacement

被引：1364

作者：

Huang, LR ^{[1
]}

Cox, EC

Austin, RH

Sturm, JC

机构：

[1] Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[3] Princeton Univ, Princeton Inst Sci & Technol Mat, Dept Phys, Princeton, NJ 08544 USA

来源：

SCIENCE | 2004年 / 304卷 / 5673期

关键词：

D O I：

10.1126/science.1094567

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40 seconds with a resolution of similar to10 nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of similar to12%.

引用

页码：987 / 990

页数：4

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