Residual Solvent Signal of CDCl3 as a qNMR Internal Standard for Application in Organic Chemistry Laboratory

被引：15

作者：

Muhamadejev, Ruslan ^{[1
]}

Melngaile, Renate ^{[1
]}

Paegle, Paula ^{[1
]}

Zibarte, Ieva ^{[1
]}

Petrova, Marina ^{[1
]}

Jaudzems, Kristaps ^{[1
]}

Veliks, Janis ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 05期

关键词：

Financial support by the Latvian Council of Science project LZP-2019/1-0258. The authors wish to thank Prof. Dr. Aigars Jirgensons for scientific discussion. Dr. Juris Popelis for NMR service. P.P. and I.Z. wish to thank Riga State Gymnasium Nr. 2;

D O I：

10.1021/acs.joc.0c02744

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nuclear magnetic resonance (NMR) spectrometer is a key instrument in the organic synthesis laboratory for structure determination, reaction control, and compound purity analysis. In addition to qualitative analysis, the application of NMR for quantitative analysis (qNMR) is gaining popularity. qNMR allows for simple quantification of crude product mixtures, determination of reaction yields, and purity of organic compounds. The determination of NMR yield requires the addition of an internal standard to each sample. Herein, we report a method where CDCl3 residual solvent signal is used as an internal standard for qNMR after quantification in the solvent batch. This method significantly simplifies sample preparation and allows straightforward recovery of the analyte by the simple evaporation of the NMR solvent. The accuracy of the method is comparable to qNMR with 1,3,5-trimethoxybenzene as an internal standard if the herein described guidelines are followed.

引用

页码：3890 / 3896

页数：7

共 22 条

[1] Concentration measurement by proton NMR using the ERETIC method [J].