OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

被引：437
作者：
Van der Flier, Laurens G.
Haegebarth, Andrea
Stange, Daniel E.
Van de Wetering, Marc
Clevers, Hans [1 ]
机构：
[1] KNAW, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands
来源：
GASTROENTEROLOGY | 2009年 / 137卷 / 01期
关键词：
BETA-CATENIN; COLON-CANCER; IDENTIFICATION; ACTIVATION; EXPRESSION; COMPLEX; CRYPTS;
D O I：
10.1053/j.gastro.2009.05.035
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
[No abstract available]
引用
收藏
页码：15 / 17
页数：3
相关论文
共 23 条
[1]   Tracking down the stem cells of the intestine: Strategies to identify adult stem cells [J].
Barker, Nick ;
Clevers, Hans .
GASTROENTEROLOGY, 2007, 133 (06) :1755-1760
[2]   The intestinal stem cell [J].
Barker, Nick ;
van de Wetering, Marc ;
Clevers, Hans .
GENES & DEVELOPMENT, 2008, 22 (14) :1856-1864
[3]   Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].
Barker, Nick ;
van Es, Johan H. ;
Kuipers, Jeroen ;
Kujala, Pekka ;
van den Born, Maaike ;
Cozijnsen, Miranda ;
Haegebarth, Andrea ;
Korving, Jeroen ;
Begthel, Harry ;
Peters, Peter J. ;
Clevers, Hans .
NATURE, 2007, 449 (7165) :1003-U1
[4]   Crypt stem cells as the cells-of-origin of intestinal cancer [J].
Barker, Nick ;
Ridgway, Rachel A. ;
van Es, Johan H. ;
van de Wetering, Marc ;
Begthel, Harry ;
van den Born, Maaike ;
Danenberg, Esther ;
Clarke, Alan R. ;
Sansom, Owen J. ;
Clevers, Hans .
NATURE, 2009, 457 (7229) :608-U119
[5]   Phenotypic characterization of human colorectal cancer stem cells [J].
Dalerba, Piero ;
Dylla, Scott J. ;
Park, In-Kyung ;
Liu, Rui ;
Wang, Xinhao ;
Cho, Robert W. ;
Hoey, Timothy ;
Gurney, Austin ;
Huang, Emina H. ;
Simeone, Diane M. ;
Shelton, Andrew A. ;
Parmiani, Giorgio ;
Castelli, Chiara ;
Clarke, Michael F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) :10158-10163
[6]   Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation [J].
Inomata, Hidehiko ;
Haraguchi, Tomoko ;
Sasai, Yoshiki .
CELL, 2008, 134 (05) :854-865
[7]   Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma [J].
Korinek, V ;
Barker, N ;
Morin, PJ ;
vanWichen, D ;
deWeger, R ;
Kinzler, KW ;
Vogelstein, B ;
Clevers, H .
SCIENCE, 1997, 275 (5307) :1784-1787
[8]   Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 [J].
Korinek, V ;
Barker, N ;
Moerer, P ;
van Donselaar, E ;
Huls, G ;
Peters, PJ ;
Clevers, H .
NATURE GENETICS, 1998, 19 (04) :379-383
[9]   Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors [J].
Kosinski, Cynthia ;
Li, Vivian S. W. ;
Chan, Annie S. Y. ;
Zhang, Ji ;
Ho, Coral ;
Tsui, Wai Yin ;
Chan, Tsun Leung ;
Mifflin, Randy C. ;
Powell, Don W. ;
Yuen, Siu Tsan ;
Leung, Suet Yi ;
Chen, Xin .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15418-15423
[10]   Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 [J].
Kuhnert, F ;
Davis, CR ;
Wang, HT ;
Chu, P ;
Lee, M ;
Yuan, J ;
Nusse, R ;
Kuo, CJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :266-271
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