pH-Dependent Fe (II) pathophysiology and protective effect of an organoselenium compound

被引：21

作者：

Hassan, Waseem ^{[1
]}

Ibrahim, Mohammad ^{[1
]}

Deobald, Anna Maria ^{[1
]}

Braga, Antonio Luiz ^{[1
]}

Nogueira, Cristina Wayne ^{[1
]}

Rocha, Joao B. T. ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

FEBS LETTERS | 2009年 / 583卷 / 06期

关键词：

pH; Lipid peroxidation; Organoselenium compound; HABER-WEISS CYCLE; LIPID-PEROXIDATION; IRON; TRANSFERRIN; RELEASE; ASSAY;

D O I：

10.1016/j.febslet.2009.02.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Influence of pH on the extent of lipid peroxidation and the anti-oxidant potential of an organoselenium compound is explored. Acidosis increased the rate of lipid peroxidation both in the absence and presence of Fe (II) in rat's brain, kidney and liver homogenate and phospholipids extract from egg yolk. The organoselenium compound significantly protected lipids from peroxidation, both in the absence and presence of Fe (II). Changing the pH of the reaction medium did not alter the anti-oxidant activity of the tested compound. This study provides in vitro evidence for acidosis-induced oxidative stress in brain, kidney, liver homogenate and phospholipids extract and the anti-oxidant action of the tested organoselenium compound. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1011 / 1016

页数：6

共 21 条

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