Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2 mediated SARS-CoV-2 entry

被引：24

作者：

Ragia, Georgia ^{[1
]}

Manolopoulos, Vangelis G. ^{[1
,2
]}

机构：

[1] Democritus Univ Thrace, Med Sch, Lab Pharmacol, Alexandroupolis 68100, Greece

[2] Acad Gen Hosp Alexandroupolis, Clin Pharmacol & Pharmacogenet Unit, Alexandroupolis 68100, Greece

来源：

PHARMACOGENOMICS | 2020年 / 21卷 / 18期

关键词：

(epi)genetics; ACE2; ADAM-17; COVID-19; FURIN; genetic classifier; SARS-CoV-2; TMPRSS2; ANGIOTENSIN-CONVERTING ENZYME; ANDROGEN RECEPTOR; DNA METHYLATION; ESTROGEN; POLYMORPHISMS; EXPRESSION; ASSOCIATION; TISSUE; TMPRSS2; CANCER;

D O I：

10.2217/pgs-2020-0092

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is considerable variation in disease course among individuals infected with SARS-CoV-2. Many of them do not exhibit any symptoms, while some others proceed to develop COVID-19; however, severity of COVID-19 symptoms greatly differs among individuals. Focusing on the early events related to SARS-CoV-2 entry to cells through the ACE2 pathway, we describe how variability in (epi)genetic factors can conceivably explain variability in disease course. We specifically focus on variations in ACE2, TMPRSS2 and FURIN genes, as central components for SARS-CoV-2 infection, and on other molecules that modulate their expression such as CALM, ADAM-17, AR and ESRs. We propose a genetic classifier for predicting SARS-CoV-2 infectivity potential as a preliminary tool for identifying the at-risk-population. This tool can serve as a dynamic scaffold being updated and adapted to validated (epi)genetic data. Overall, the proposed approach holds potential for better personalization of COVID-19 handling.

引用

页码：1311 / 1329

页数：19

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