Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes

被引:2
作者
Kirkiacharian, S
Koutsourakis, PG
Philibert, D
Bouchoux, F
Van de Velde, P
机构
[1] Fac Pharm Paris Sud, Chim Therapeut Lab, F-92226 Chatenay Malabry, France
[2] Grp HMR, Lab Physiol Hormones, Labs Roussel, F-93230 Romainville, France
来源
FARMACO | 1999年 / 54卷 / 10期
关键词
binding affinity; steroid receptor; antiproliferative activity;
D O I
10.1016/S0014-827X(99)00080-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three derivatives. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:678 / 683
页数:6
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