Three-Component Coupling of Isoquinoline, Activated Alkyne and Nitromethane: A Facile Synthesis of Nitromethyl Derivatives of 1,2-Dihydroisoquinolines

被引：13

作者：

Yadav, Jhillu S. ^{[1
]}

Reddy, Basi V. Subba ^{[1
]}

Yadav, Nagendra Nath ^{[1
]}

Gupta, Manoj K. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2009年 / 07期

关键词：

aza-Henry reaction; isoquinoline/quinoline; activated alkynes; nitromethane; DIMETHYL ACETYLENEDICARBOXYLATE; ENANTIOSELECTIVE ADDITION; BIFUNCTIONAL CATALYST; REISSERT; CHLOROFORMATE; CONSTRUCTION; HETEROCYCLES; ALLYLATION; ACETYLENES; PHOSPHINES;

D O I：

10.1055/s-0028-1088004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component coupling (3CC) of isoquinoline, activated alkynes and nitromethane has been achieved for the First time to produce nitromethyl derivatives of dihydroisoquinoline in excellent yields with high selectivity. The reaction proceeds smoothly at 25 degrees C without catalyst.

引用

页码：1131 / 1136

页数：6

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