Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant

被引：25

作者：

Ge, Jianhua ^{[1
,2
]}

Zhang, Yi ^{[3
]}

Dong, Zhirui ^{[1
,2
]}

Jia, Jianbo ^{[3
]}

Zhu, Jiannan ^{[1
,2
]}

Miao, Xiaoyuan ^{[3
]}

Yan, Bing ^{[3
]}

机构：

[1] Shandong Univ, Minist Educ, Key Lab Liquid Solid Struct Evolut & Proc Mat, Jinan 250061, Peoples R China

[2] Shandong Univ, Sch Mat Sci & Engn, Jinan 250100, Peoples R China

[3] Shandong Univ, Sch Environm Sci & Engn, Jinan 250100, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 24期

基金：

中国国家自然科学基金;

关键词：

magnetic implant; drug delivery; nanocarrier; nanomedicine; targeting; TISSUE ENGINEERING SCAFFOLDS; SIMULATED BODY-FLUID; DRUG-DELIVERY; NANOPARTICLES; RELEASE; DEGRADATION; HYDROXYAPATITE; REGENERATION; COMPOSITES; CELLULOSE;

D O I：

10.1021/acsami.7b05009

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments.

引用

页码：20771 / 20778

页数：8

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