Exploring the role of non-coding RNAs in autophagy

被引：48

作者：

Ghafouri-Fard, Soudeh ^{[1
]}

Shoorei, Hamed ^{[2
]}

Mohaqiq, Mahdi ^{[3
]}

Majidpoor, Jamal ^{[4
]}

Mossavi, Mohammad Amin ^{[5
]}

Taheri, Mohammad ^{[6
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran

[2] Birjand Univ Med Sci, Dept Anat Sci, Fac Med, Birjand, Iran

[3] Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC USA

[4] Iran Univ Med Sci, Sch Med, Dept Anat, Tehran, Iran

[5] Inst Med Biotechnol, Natl Inst Genet Engn & Biotechnol, Dept Mol Med, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, POB 1985717443, Tehran, Iran

来源：

AUTOPHAGY | 2022年 / 18卷 / 05期

关键词：

Autophagy; biomarker; cancer; lncRNAs; microRNAs; APOPTOSIS; VIABILITY; PATHWAY;

D O I：

10.1080/15548627.2021.1883881

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As a self-degradative mechanism, macroautophagy/autophagy has a role in the maintenance of energy homeostasis during critical periods in the development of cells. It also controls cellular damage through the eradication of damaged proteins and organelles. This process is accomplished by tens of ATG (autophagy-related) proteins. Recent studies have shown the involvement of non-coding RNAs in the regulation of autophagy. These transcripts mostly modulate the expression of ATG genes. Both long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been shown to modulate the autophagy mechanism. Levels of several lncRNAs and miRNAs are altered in this process. In the present review, we discuss the role of lncRNAs and miRNAs in the regulation of autophagy in diverse contexts such as cancer, deep vein thrombosis, spinal cord injury, diabetes and its complications, acute myocardial infarction, osteoarthritis, pre-eclampsia and epilepsy.

引用

页码：949 / 970

页数：22

共 75 条

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