Cardiac Remodeling: Concepts, Clinical Impact, Pathophysiological Mechanisms and Pharmacologic Treatment

被引：199

作者：

Azevedo, Paula S. ^{[1
]}

Polegato, Bertha F. ^{[1
]}

Minicucci, Marcos F. ^{[1
]}

Paiva, Sergio A. R. ^{[1
]}

Zornoff, Leonardo A. M. ^{[1
]}

机构：

[1] Fac Med Botucatu, Sao Paulo, SP, Brazil

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2016年 / 106卷 / 01期

关键词：

Ventricular Remodeling; Heart Failure; Medication Therapy Management; Ventricular Dysfunction / physiopathology; HEART-FAILURE; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; MOLECULAR-MECHANISMS; HYPERTROPHY; FIBROSIS; DISEASE; DYSFUNCTION; SYSTEM; METABOLISM;

D O I：

10.5935/abc.20160005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that manifest clinically as changes in size, mass, geometry and function of the heart after injury. The process results in poor prognosis because of its association with ventricular dysfunction and malignant arrhythmias. Here, we discuss the concepts and clinical implications of cardiac remodeling, and the pathophysiological role of different factors, including cell death, energy metabolism, oxidative stress, inflammation, collagen, contractile proteins, calcium transport, geometry and neurohormonal activation. Finally, the article describes the pharmacological treatment of cardiac remodeling, which can be divided into three different stages of strategies: consolidated, promising and potential strategies.

引用

页码：62 / 69

页数：8

共 52 条

[1] Noninvasive assessment of left ventricular remodeling: Concepts, techniques, and implications for clinical trials [J].