Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells

被引：48

作者：

Zhang, Haiyang ^{[1
]}

Zhong, Xia ^{[1
]}

Zhang, Xiao ^{[2
]}

Shang, Deya ^{[1
]}

Zhou, Yi ^{[1
]}

Zhang, Chunqing ^{[3
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Emergency, Jinan 250021, Shandong, Peoples R China

[2] Shandong Ctr Dis Control & Prevent, Jinan 250014, Shandong, Peoples R China

[3] Shandong Univ, Shandong Prov Hosp, Dept Internal Med, Div Hepatogastroenterol, 324 Jingwu Weiqi Rd, Jinan 250021, Shandong, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2016年 / 11卷 / 02期

关键词：

ABT-737; naringenin; gastric cancer; anticancer; BH3 MIMETIC ABT-737; CARCINOMA CELLS; DOWN-REGULATION; APOPTOSIS; FLAVONOIDS; AKT; CARCINOGENESIS; MECHANISMS; SURVIVAL; LEUKEMIA;

D O I：

10.3892/etm.2015.2912

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gastric cancer is the second leading cause of cancer-associated mortality and is a frequently occurring cancer worldwide. Multiple drug resistance of gastric cancer cells leads to the poor prognosis. In addition, overexpression of anti-apoptotic protein B-cell lymphoma (Bcl)-2 have been demonstrated in various cancer cells and is closely associated with drug resistance and poor prognosis. Naringenin is a flavonoid that has antimutagenic and anticarcinogenic activities in numerous cancer types. In the present study, naringenin and a Bcl-2 inhibitor, ABT-737, were used to investigate their combinative anticancer effect in the SGC7901 gastric cancer cell line. The results revealed that naringenin and ABT-737 were able to inhibit SGC7901 cell growth and colony formation, alone or in combination. Furthermore, the combination of these drugs was found to further increase the cleavage of caspase-3 and poly ADP-ribose polymerase. Naringenin and ABT-737 also decreased Akt activation and increased p53 expression, suggesting the involvement of these pathways in the inhibition of gastric cell growth.

引用

页码：669 / 673

页数：5

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