Acetylcholinesterase inhibitors from the roots of Angelica dahurica

被引：54

作者：

Kim, DK ^{[1
]}

Lim, JP ^{[1
]}

Yang, JH ^{[1
]}

Eom, DO ^{[1
]}

Eun, JS ^{[1
]}

Leem, KH ^{[1
]}

机构：

[1] Woosuk Univ, Coll Pharm, Samrye 565701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 06期

关键词：

Angelica dahurica; anticholinesterase activity; isoimperatorin; imperatorin; oxypeucedanin;

D O I：

10.1007/BF02977004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1-3 were 74.6, 63.7 and 89.1 uM, respectively.

引用

页码：856 / 859

页数：4

共 19 条

[1] Furanocoumarins from the root of Angelica dahurica [J].