共 34 条
Serum IL-6 Level May Have Role in the Pathophysiology of Unexplained Infertility
被引:42
作者:
Demir, Bulent
[1
]
Guven, Suleyman
[2
]
Guven, Emine Seda Guvendag
[3
]
Atamer, Yildiz
[4
]
Gul, Talip
[5
]
机构:
[1] Ergani Govt Hosp, Obstet & Gynecol Clin, Minist Hlth, Diyarbakir, Turkey
[2] Karadeniz Tech Univ, Sch Med, Dept Obstet & Gynecol, Trabzon, Turkey
[3] Rize Univ, Sch Med, Dept Obstet & Gynecol, Rize, Turkey
[4] Dicle Univ, Fac Med, Dept Biochem, Diyarbakir, Turkey
[5] Dicle Univ, Sch Med, Dept Obstet & Gynecol, Diyarbakir, Turkey
关键词:
IL-6;
pathophysiology;
serum level;
TNF-alpha;
unexplained infertility;
ENDOMETRIOSIS-ASSOCIATED INFERTILITY;
DIMINISHED OVARIAN RESERVE;
TUMOR-NECROSIS-FACTOR;
PERITONEAL-FLUID;
IN-VITRO;
REDUCED EXPRESSION;
CYTOKINES;
INTERLEUKIN-6;
FERTILIZATION;
WOMEN;
D O I:
10.1111/j.1600-0897.2009.00734.x
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Problem The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects. Method of study Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study. Results The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups. Conclusion Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.
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页码:261 / 267
页数:7
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