Serum IL-6 Level May Have Role in the Pathophysiology of Unexplained Infertility

被引:42
作者
Demir, Bulent [1 ]
Guven, Suleyman [2 ]
Guven, Emine Seda Guvendag [3 ]
Atamer, Yildiz [4 ]
Gul, Talip [5 ]
机构
[1] Ergani Govt Hosp, Obstet & Gynecol Clin, Minist Hlth, Diyarbakir, Turkey
[2] Karadeniz Tech Univ, Sch Med, Dept Obstet & Gynecol, Trabzon, Turkey
[3] Rize Univ, Sch Med, Dept Obstet & Gynecol, Rize, Turkey
[4] Dicle Univ, Fac Med, Dept Biochem, Diyarbakir, Turkey
[5] Dicle Univ, Sch Med, Dept Obstet & Gynecol, Diyarbakir, Turkey
关键词
IL-6; pathophysiology; serum level; TNF-alpha; unexplained infertility; ENDOMETRIOSIS-ASSOCIATED INFERTILITY; DIMINISHED OVARIAN RESERVE; TUMOR-NECROSIS-FACTOR; PERITONEAL-FLUID; IN-VITRO; REDUCED EXPRESSION; CYTOKINES; INTERLEUKIN-6; FERTILIZATION; WOMEN;
D O I
10.1111/j.1600-0897.2009.00734.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Problem The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects. Method of study Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study. Results The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups. Conclusion Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.
引用
收藏
页码:261 / 267
页数:7
相关论文
共 34 条
[1]   Management of long-standing unexplained infertility: A prospective study [J].
Aboulghar, MA ;
Mansour, RT ;
Serour, GI ;
Amin, Y ;
Ramzy, AM ;
Sattar, MA ;
Kamal, A .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1999, 181 (02) :371-375
[2]   THE POTENTIAL RELEVANCE OF CYTOKINES TO OVARIAN PHYSIOLOGY - THE EMERGING ROLE OF RESIDENT OVARIAN-CELLS OF THE WHITE BLOOD-CELL SERIES [J].
ADASHI, EY .
ENDOCRINE REVIEWS, 1990, 11 (03) :454-464
[3]   Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles [J].
Amato, G ;
Conte, M ;
Mazziotti, G ;
Lalli, E ;
Vitolo, G ;
Tucker, AT ;
Bellastella, A ;
Carella, C ;
Izzo, A .
OBSTETRICS AND GYNECOLOGY, 2003, 101 (06) :1177-1182
[4]   Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial [J].
Bedaiwy, MA ;
Falcone, T ;
Sharma, RK ;
Goldberg, JM ;
Attaran, M ;
Nelson, DR ;
Agarwal, A .
HUMAN REPRODUCTION, 2002, 17 (02) :426-431
[5]   Unexplained infertility: Evaluation of the luteal phase; Results of the National Center for Infertility Research at Michigan [J].
Blacker, CM ;
Ginsburg, KA ;
Leach, RE ;
Randolph, J ;
Moghissi, KS .
FERTILITY AND STERILITY, 1997, 67 (03) :437-442
[6]   Endometriosis is sustained by tumour necrosis factor-α [J].
Bullimore, DW .
MEDICAL HYPOTHESES, 2003, 60 (01) :84-88
[7]   Management of infertility [J].
Cahill, DJ ;
Wardle, PG .
BMJ-BRITISH MEDICAL JOURNAL, 2002, 325 (7354) :28-32
[8]   Reduction of estrogen production by interleukin-6 in a human granulosa tumor cell line may have implications for endometriosis-associated infertility [J].
Deura, I ;
Harada, T ;
Taniguchi, F ;
Iwabe, T ;
Izawa, M ;
Terakawa, N .
FERTILITY AND STERILITY, 2005, 83 :1086-1092
[9]   T-helper 2 and 3 type immunity to trophoblast in successful in vitro fertilization-embryo transfer [J].
Ginsburg, ES ;
Xiao, L ;
Gargiulo, AR ;
Kung, FT ;
Politch, JA ;
Schust, DJ ;
Hill, JA .
FERTILITY AND STERILITY, 2005, 83 (06) :1659-1664
[10]   Efficacy of superovulation and intrauterine insemination in the treatment of infertility [J].
Guzick, DS ;
Carson, SA ;
Coutifaris, C ;
Overstreet, JW ;
Factor-Litvak, P ;
Steinkampf, MP ;
Hill, JA ;
Mastroianni, L ;
Buster, JE ;
Nakajima, ST ;
Vogel, DL ;
Canfield, RE .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (03) :177-183