Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment

被引：949

作者：

Romano, M

Sironi, M

Toniatti, C

Polentarutti, N

Fruscella, P

Ghezzi, P

Faggioni, R

Luini, W

vanHinsbergh, V

Sozzani, S

Bussolino, F

Poli, V

Ciliberto, G

Mantovani, A

机构：

[1] IST RIC FARMACOL MARIO NEGRI,MILAN,ITALY

[2] UNIV BRESCIA,DEPT BIOTECHNOL,SECT PATHOL & IMMUNOL,I-25121 BRESCIA,ITALY

[3] IST RIC BIOL MOL P ANGELETTI,ROME,ITALY

[4] UNIV TURIN,DIPARTIMENTO GENET BIOL & CHIM MED,I-10124 TURIN,ITALY

[5] TNO,PG,GAUBIUS LAB,LEIDEN,NETHERLANDS

来源：

IMMUNITY | 1997年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(00)80334-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-6(-/-) mice showed impaired leukocyte accumulation in subcutaneous air pouches. Defective leukocyte accumulation was not due to a reduced migratory capacity of IL-6(-/-) leukocytes and was associated with a reduced in situ production of chemokines. These observations led to a reexamination of the interaction of IL-6 with endothelial cells (EC). Sc express only the gp130 signal transducing chain and not the subunit-specific IL-6R and are therefore unresponsive to IL-6. However, EC are responsive to a combination of IL-6 and soluble IL-6R as measured by the activation of STATE, chemokine expression, and augmentation of ICAM-1. Activation by IL-6-IL-6R complexes was inhibited by an IL-6 receptor antagonist and potentiated by a superagonist. Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment.

引用

页码：315 / 325

页数：11

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