Development of a LC-MS/MS Method for the Quantification of Myricitrin: Application to a Pharmacokinetic Study in Rats

被引：2

作者：

Wang, Yan ^{[1
]}

Fan, Youjin ^{[1
]}

Deng, Zhipeng ^{[2
]}

Wu, Weihong ^{[3
]}

Liu, Jia ^{[4
]}

Wang, Hong ^{[1
]}

机构：

[1] Jiaozhou Peoples Hosp, Qingdao 266300, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Sch Pharmaceut Sci, Jinan 250355, Peoples R China

[3] Shandong Med Coll, Jinan 250002, Peoples R China

[4] Shandong First Med Univ & Shandong Acad Med Sci, Inst Mat Med, Jinan 250062, Peoples R China

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2021年 / 31卷 / 01期

关键词：

Flavonoid glycoside; Liquid chromatography; Method validation; Myricitrin; Myrycaceae; Tandem mass spectrometry;

D O I：

10.1007/s43450-020-00121-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A highly sensitive reversed-phase liquid chromatography coupled to tandem mass spectrometry for the quantification of myricitrin in rat plasma was developed and validated using orientin as an internal standard. The detection was achieved on a triple-quadrupole mass spectrometer using selected reaction monitoring mode in the negative electrospray ionization source. Linearity was constructed over a concentration range of 2.0-1000 ng/ml for myricitrin. The sensitivity and accuracy of the method allowed determination of the pharmacokinetics of myricitrin in rats following intravenous administration in male rats. Graphical

引用

页码：102 / 106

页数：5

共 17 条

[1] Antioxidant effect of myricitrin on hyperglycemia-induced oxidative stress in C2C12 cell [J].

Ahangarpour, Akram ;

Oroojan, Ali Akbar ;

Khorsandi, Layasadat ;

Kouchak, Maryam ;

Badavi, Mohammad .

CELL STRESS & CHAPERONES, 2018, 23 (04) :773-781

[2] Myricitrin Inhibits Acrylamide-Mediated Cytotoxicity in Human Caco-2 Cells by Preventing Oxidative Stress [J].

Chen, Wei ;

Feng, Lina ;

Shen, Yang ;

Su, Hongming ;

Li, Ya ;

Zhuang, Jingjing ;

Zhang, Lingxia ;

Zheng, Xiaodong .

BIOMED RESEARCH INTERNATIONAL, 2013, 2013

[3] Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice [J].

Domitrovic, Robert ;

Rashed, Khaled ;

Cvijanovic, Olga ;

Vladimir-Knezevic, Sanda ;

Skoda, Marko ;

Visnic, Alenka .

CHEMICO-BIOLOGICAL INTERACTIONS, 2015, 230 :21-29

[4]

Food and Drug Administration (FDA), 2018, BIOAN METH VAL

[5] Myricitrin exhibits anti-atherosclerotic and anti-hyperlipidemic effects in diet-induced hypercholesterolemic rats [J].

Gao, Jing ;

Liu, Cuicui ;

Zhang, Heping ;

Sun, Zhen ;

Wang, Rongmei .

AMB EXPRESS, 2019, 9 (01)

[6] Myricitrin protects against cisplatin-induced kidney injury by eliminating excessive reactive oxygen species [J].

Li, Ruiqian ;

Hu, Libing ;

Hu, Chen ;

Wang, Qiling ;

Lei, Yonghong ;

Zhao, Bin .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2020, 52 (01) :187-196

[7] Chemical Study on Protective Effect Against Hydroxyl- induced DNA Damage and Antioxidant Mechanism of Myricitrin [J].

Li, Xican ;

Mai, Wenqiong ;

Chen, Dongfeng .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2014, 61 (03) :383-390

[8] Improved oral bioavailability of myricitrin by liquid self-microemulsifying drug delivery systems [J].

Man, Na ;

Wang, Qilong ;

Li, Huihua ;

Adu-Frimpong, Michael ;

Sun, Congyong ;

Zhang, Kangyi ;

Yang, Qiuxuan ;

Wei, Qiuyu ;

Ji, Hao ;

Toreniyazov, Elmurat ;

Yu, Jiangnan ;

Xu, Ximing .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 52 :597-606

[9] Safety assessment and single-dose toxicokinetics of the flavouring agent myricitrin in Sprague-Dawley rats [J].

Maronpot, Robert R. ;

Koyanagi, Mihoko ;

Davis, Jeffrey ;

Recio, Leslie ;

Marbury, Dean ;

Boyle, Molly ;

Hayashi, Shim-mo .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2015, 32 (11) :1799-1809

[10]

MATSUDA H, 1995, BIOL PHARM BULL, V18, P1148, DOI 10.1248/bpb.18.1148

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