The roles of microbial products in the development of colorectal cancer: a review

被引：95
作者：
Fang, Yongkun [1 ]
Yan, Cheng [1 ]
Zhao, Qi [2 ]
Xu, Jiaming [3 ]
Liu, Zhuangzhuang [1 ]
Gao, Jin [1 ]
Zhu, Hanjian [2 ]
Dai, Zhujiang [2 ]
Wang, Daorong [3 ]
Tang, Dong [3 ]
机构：
[1] Dalian Med Univ, Dept Clin Med Coll, Dalian, Liaoning, Peoples R China
[2] Yangzhou Univ, Dept Clin Med Coll, Yangzhou, Jiangsu, Peoples R China
[3] Yangzhou Univ, Inst Gen Surg, Clin Med Coll, Dept Gen Surg, Yangzhou, Jiangsu, Peoples R China
来源：
BIOENGINEERED | 2021年 / 12卷 / 01期
关键词：
Human gut microbiome; colorectal cancer; metabolism; short-chain fatty acids; secondary bile salts; bacterial toxin; TRIMETHYLAMINE-N-OXIDE; ENTEROTOXIGENIC BACTEROIDES-FRAGILIS; ACETATE-INDUCED APOPTOSIS; COLON-CANCER; BILE-ACIDS; GUT MICROBIOTA; URSODEOXYCHOLIC ACID; HYDROGEN-SULFIDE; GASTROINTESTINAL-TRACT; INTESTINAL MICROBIOTA;
D O I：
10.1080/21655979.2021.1889109
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A large number of microbes exist in the gut and they have the ability to process and utilize ingested food. It has been reported that their products are involved in colorectal cancer development. The molecular mechanisms which underlie the relationship between gut microbial products and CRC are still not fully understood. The role of some microbial products in CRC is particularly controversial. Elucidating the effects of gut microbiota products on CRC and their possible mechanisms is vital for CRC prevention and treatment. In this review, recent studies are examined in order to describe the contribution metabolites and toxicants which are produced by gut microbes make to CRC, primarily focusing on the involved molecular mechanisms.
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收藏
页码：720 / 735
页数：16
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