ATR-FTIR and Raman spectroscopic investigation of the electroporation-mediated transdermal delivery of a nanocarrier system containing an antitumour drug

被引：24

作者：

Balazs, Boglarka ^{[1
,2
]}

Sipos, Peter ^{[1
]}

Danciu, Corina ^{[3
]}

Avram, Stefana ^{[4
]}

Soica, Codruta ^{[5
]}

Dehelean, Cristina ^{[6
]}

Varju, Gabor ^{[7
]}

Eros, Gabor ^{[8
,9
]}

Budai-Szucs, Maria ^{[1
]}

Berko, Szilvia ^{[1
]}

Csanyi, Erzsebet ^{[1
]}

机构：

[1] Univ Szeged, Dept Pharmaceut Technol, H-6720 Szeged, Hungary

[2] Gedeon Richter Plc, H-1103 Budapest, Hungary

[3] Victor Babes Univ Med & Pharm, Dept Pharmacognosy, Timisoara 300041, Romania

[4] Victor Babes Univ Med & Pharm, Discipline Pharmacol, Timisoara 300041, Romania

[5] Victor Babes Univ Med & Pharm, Discipline Pharmaceut Chem, Timisoara 300041, Romania

[6] Victor Babes Univ Med & Pharm, Dept Toxicol, Timisoara 300041, Romania

[7] Dr Derm Clin Antiaging Dermatol Aesthet Laser & P, H-1026 Budapest, Hungary

[8] Univ Szeged, Dept Dermatol & Allergol, H-6720 Szeged, Hungary

[9] Univ Szeged, Dept Oral Biol & Expt Dent Res, H-6720 Szeged, Hungary

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 01期

关键词：

IN-VIVO; STRATUM-CORNEUM; SKIN; GENISTEIN; MODEL; VITRO;

D O I：

10.1364/BOE.7.000067

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present work was the optimization of the transdermal delivery of a lyotropic liquid crystal genistein-based formulation (LLC-GEN). LLC was chosen as medium in view of the poor solubility of GEN in water. Membrane diffusion and penetration studies were carried out with a Franz diffusion cell, through a synthetic membrane in vitro, a chick chorioallantoic membrane ex ovo, and ex vivo excised human epidermis. Thereafter, LLC-GEN was combined with electroporation (EP) to enhance the transdermal drug delivery. The synergistic effect of EP was verified by in vivo ATR-FTIR and ex vivo Raman spectroscopy on hairless mouse skin. (C)2015 Optical Society of America

引用

页码：67 / 78

页数：12

共 31 条

[1] Physical characterization of the stratum corneum of an in vitro psoriatic skin model by ATR-FTIR and Raman spectroscopies [J].

Bernard, Genevieve ;

Auger, Michele ;

Soucy, Jacques ;

Pouliot, Roxane .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2007, 1770 (09) :1317-1323

[2] EXAMINATION OF STRATUM-CORNEUM BARRIER FUNCTION INVIVO BY INFRARED-SPECTROSCOPY [J].

BOMMANNAN, D ;

POTTS, RO ;

GUY, RH .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (04) :403-408

[3] Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems [J].

Boyd, BJ ;

Whittaker, DV ;

Khoo, SM ;

Davey, G .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 309 (1-2) :218-226

[4] In-vitro human skin penetration of the fragrance material geranyl nitrile [J].

Brain, K. R. ;

Green, D. M. ;

Lalko, J. ;

Api, A. M. .

TOXICOLOGY IN VITRO, 2007, 21 (01) :133-138

[5] The effect of hydrogen bond on the vibrational dynamics of genistein free and complexed with β-cyclodextrins [J].

Crupi, Vincenza ;

Majolino, Domenico ;

Paciaroni, Alessandro ;

Rossi, Barbara ;

Stancanelli, Rosanna ;

Venuti, Valentina ;

Viliani, Gabriele .

JOURNAL OF RAMAN SPECTROSCOPY, 2010, 41 (07) :764-770

[6] Ibuprofen penetration enhance by sucrose ester examined by ATR-FTIR in vivo [J].

Csizmazia, Eszter ;

Eros, Gabor ;

Berkesi, Otto ;

Berko, Szilvia ;

Szabo-Revesz, Piroska ;

Csanyi, Erzsebet .

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2012, 17 (01) :125-128

[7]

Danciu C, 2015, REV CHIM-BUCHAREST, V66, P1038

[8] The Effect of Electroporation of a Lyotroic Liquid Crystal Genistein-Based Formulation in the Recovery of Murine Melanoma Lesions [J].

Danciu, Corina ;

Berko, Szilvia ;

Varju, Gabor ;

Balazs, Boglarka ;

Kemeny, Lajos ;

Nemeth, Istvan Balazs ;

Cioca, Andreea ;

Petrus, Alexandra ;

Dehelean, Cristina ;

Cosmin, Citu Ioan ;

Amaricai, Elena ;

Toma, Claudia Crina .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (07) :15425-15441

[9]

Danciu C, 2013, NAT PROD COMMUN, V8, P343

[10] Skin electroporation for transdermal and topical delivery [J].

Denet, AR ;

Vanbever, R ;

Préat, V .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (05) :659-674

← 1 2 3 4 →