On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds

被引：283

作者：

Casadevall, Arturo ^{[1
]}

Kontoyiannis, Dimitrios P. ^{[2
]}

Robert, Vincent ^{[3
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[2] Univ Texas MD Anderson Canc Ctr, Div Internal Med, Houston, TX 77030 USA

[3] Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands

来源：

MBIO | 2019年 / 10卷 / 04期

关键词：

Candida; climate change; fungus; VIRULENCE; ALBICANS; GENOME; NOV;

D O I：

10.1128/mBio.01397-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The most enigmatic aspect of the rise of Candida auris as a human pathogen is that it emerged simultaneously on three continents, with each Glade being genetically distinct. Although new pathogenic fungal species are described regularly, these are mostly species associated with single cases in individuals who are immunosuppressed. In this study, we used phylogenetic analysis to compare the temperature susceptibility of C. auris with those of its close relatives and to use these results to argue that it may be the first example of a new fungal disease emerging from climate change, with the caveat that many other factors may have contributed.

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