The Gut Microbiota in Causation, Detection, and Treatment of Cancer

被引：26

作者：

Murphy, Clodagh L. ^{[1
,2
]}

O'Toole, Paul W. ^{[1
,3
]}

Shanahan, Fergus ^{[1
,2
]}

机构：

[1] Natl Univ Ireland, Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland

[2] Natl Univ Ireland, Univ Coll Cork, Dept Med, Cork, Ireland

[3] Natl Univ Ireland, Univ Coll Cork, Sch Microbiol, Cork, Ireland

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2019年 / 114卷 / 07期

基金：

爱尔兰科学基金会;

关键词：

VERSUS-HOST-DISEASE; INTESTINAL MICROBIOME; CHECKPOINT-BLOCKADE; ANTITUMOR IMMUNITY; PEDIATRIC-PATIENTS; FECAL MICROBIOTA; INDUCED DIARRHEA; CHEMOTHERAPY; PROPHYLAXIS; BACTERIA;

D O I：

10.14309/ajg.0000000000000075

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut microbiota has emerged as an important consideration in clinical oncology. The role of the microbiome in cancer extends beyond causation and cancer risk. It is now known that the microbiome not only acts at a local epithelial level in the gut but also modifies immune responses within intestinal and extraintestinal tumors. Microbial signaling influences the clinical course of cancer including the efficacy, bioavailability, and toxicity of chemotherapeutic and immunotherapy agents. This has focused research on microbiota profiling in different cancer states with an aim of developing prognostic biomarkers of risk. The potential value of microbiome manipulation with live biotherapeutics or microbial transplantation has also become a realistic consideration. Maintenance of microbial diversity in patients with cancer is a variable challenge given the modifying influences of the tumor itself, chemotherapy, nutritional status, and sporadic antimicrobial therapy. Here, we address current evidence for the role of the microbiome in cancer therapy.

引用

页码：1036 / 1042

页数：7

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