The Burden and Morphology of Premature Ventricular Contractions and their Impact on Clinical Outcomes in Patients Receiving Biventricular Pacing in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT)

被引:5
作者
Aktas, Mehmet K. [1 ]
Mittal, Suneet [2 ]
Kutyifa, Valentina [1 ]
McNitt, Scott [1 ]
Polonsky, Bronislava [1 ]
Steinberg, Jonathan [2 ]
Moss, Arthur J. [1 ]
Zareba, Wojciech [1 ]
机构
[1] Univ Rochester, Med Ctr, 601 Elmwood Ave,Box 679-C, Rochester, NY 14642 USA
[2] Columbia Univ Coll Phys & Surg, Arrhythmia Inst, Valley Hlth Syst, 630 W 168th St, New York, NY 10032 USA
关键词
noninvasive techniques; electrocardiography; clinical; implantable devices; biventricular pacing; defibrillation; OUTFLOW TRACT; RADIOFREQUENCY ABLATION; INDUCED CARDIOMYOPATHY; HEART-FAILURE; COMPLEXES; TACHYCARDIA; FREQUENT; REVERSAL; BEATS;
D O I
10.1111/anec.12268
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
IntroductionPremature ventricular contractions (PVCs) frequently occur in patients with left ventricular dysfunction. However, there are limited data regarding the burden and morphologic characteristics of PVCs in patients receiving cardiac resynchronization therapy. Methods and ResultsPatients enrolled in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) with >5000 PVCs on a predevice implant 12-lead, 24-hour Holter were identified. The putative PVC site of origin for the most dominant PVC was characterized and their effects on clinical outcomes were evaluated. A total of 146 patients were identified to have >5000 PVCs on Holter of which 75 (51%) had PVCs originating from a non-outflow tract site. Other sites included the left ventricular outflow tract (LVOT), right ventricular outflow tract (RVOT), and the sinus of Valsalva. In multivariate analysis, the risk for HF/Deatd was similar in patients with Outflow tract PVCs when compared to patients with Non-outflow tract PVCs (HR 1.4, 95% CI 0.7-2.8, P = 0.3). The degree of echocardiographic reverse remodeling was similar in patients with outflow tract versus Non-outflow tract PVCs. One-third of patients with nonischemic cardiomyopathy were found to have PVCs originating from the RVOT. ConclusionsIn patients with mild symptoms of heart failure, there is no difference in the risk of HF or death in patients with outflow versus non-outflow tract PVCs. One-third of patients with NICM have frequent PVCs originating from the RVOT.
引用
收藏
页码:41 / 48
页数:8
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