Tyrosine phosphorylation of the integrin β3 subunit regulates β3 cleavage by calpain.

被引:0
作者
Stojanovic, Aleksandra
Flevaris, Panagiotis
Xi, Xiaodong
Chisti, Athar
Phillips, David
Lam, Stephen C. -T.
Du, Xiaoping
机构
[1] Univ Illinois, Chicago, IL USA
[2] Portola Pharmaceut Inc, San Francisco, CA USA
关键词
D O I
10.1182/blood.V108.11.1524.1524
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1524
引用
收藏
页码:439A / 439A
页数:1
相关论文
共 50 条
  • [31] The α4 laminin subunit regulates recruitment of αvβ3 integrin to focal contacts
    Gonzalez, AM
    Jones, JC
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 : 174A - 174A
  • [32] Integrin αIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of β3-subunits in actin cytoskeletal organization
    Yamodo, IH
    Blystone, SD
    CELL COMMUNICATION AND ADHESION, 2004, 11 (5-6) : 121 - 135
  • [33] The β3 subunit of the integrin αIIbβ3 regulates αIIb-mediated outside-in signaling.
    Liu, JL
    Jackson, CW
    Gruppo, RA
    Jennings, LK
    Gartner, TK
    BLOOD, 2004, 104 (11) : 62B - 62B
  • [34] Phosphorylation of a conserved integrin α3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement
    Zhang, XA
    Bontrager, AL
    Stipp, CS
    Kraeft, SK
    Bazzoni, G
    Chen, LB
    Hemler, ME
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (02) : 351 - 365
  • [35] Tyrosine phosphorylation of the β3-subunit of the αVβ3 integrin is required for membrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the inslulin-like growth factor I receptor
    Ling, Y
    Maile, LA
    Clemmons, DR
    MOLECULAR ENDOCRINOLOGY, 2003, 17 (09) : 1824 - 1833
  • [36] Exposure of ligand-binding sites on platelet integrin alpha(IIB)/beta(3) by phosphorylation of the beta(3) subunit
    vanWilligen, G
    Hers, I
    Gorter, G
    Akkerman, JWN
    BIOCHEMICAL JOURNAL, 1996, 314 : 769 - 779
  • [37] Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3
    Choi, EK
    Miller, JS
    Zaidi, NF
    Salih, E
    Buxbaum, JD
    Wasco, W
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (03) : 495 - 506
  • [38] Pike tyrosine phosphorylation regulates its apoptotic cleavage during programmed cell death
    Tang, Xiaoling
    Ye, Keqiang
    ADVANCES IN ENZYME REGULATION, VOL 46, PROCEEDINGS, 2006, 46 : 289 - 300
  • [39] β3 tyrosine phosphorylation in αIIbβ3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling
    Phillips, DR
    Nannizzi-Alamio, L
    Prasad, KSS
    THROMBOSIS AND HAEMOSTASIS, 2001, 86 (01) : 246 - 258
  • [40] Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alpha(IIb)beta(3) (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots
    Schoenwaelder, SM
    Yuan, YP
    Cooray, P
    Salem, HH
    Jackson, SP
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (03) : 1694 - 1702