Chemokine polymorphisms and lymphoma: a pooled analysis

被引：21

作者：

Bracci, Paige M. ^{[1
]}

Skibola, Christine F. ^{[2
]}

Conde, Lucia ^{[2
]}

Halperin, Eran ^{[3
]}

Lightfoot, Tracy ^{[4
]}

Smith, Alex ^{[4
]}

Paynter, Randi A. ^{[2
]}

Skibola, Danica R. ^{[2
]}

Agana, Luz ^{[2
]}

Roman, Eve ^{[4
]}

Kane, Eleanor ^{[4
]}

Wiencke, John K. ^{[5
]}

机构：

[1] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA

[2] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[3] Int Comp Sci Inst, Berkeley, CA 94704 USA

[4] Univ York, Epidemiol & Genet Unit, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England

[5] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94118 USA

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 03期

关键词：

Lymphoma non-Hodgkin; chemokines; polymorphism; genetic; case-control; NON-HODGKIN-LYMPHOMA; GENETIC POLYMORPHISMS; DISEASE PROGRESSION; ATOPIC-DERMATITIS; PROSTATE-CANCER; REDUCED RISK; TNF-A; RECEPTOR; RANTES; EXPRESSION;

D O I：

10.3109/10428190903518337

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polymorphisms in chemokine genes have been associated with human immunodeficiency virus (HIV)-related non-Hodgkin lymphoma (NHL) but are understudied in non-HIV-related NHL. Associations of NHL and NHL subtypes with polymorphisms and haplotypes in CCR5, CCR2, CCL5, CXCL12, and CX(3)CR(1) were explored in a pooled analysis of three case-control studies (San Francisco Bay Area, California; United Kingdom; total: cases N = 1610, controls N = 1992). Adjusted unconditional logistic regression was used to estimate relative risks among HIV-negative non-Hispanic Caucasians. The CCR5 delta 32 deletion reduced the risk of NHL (odds ratio = 0.56, 95% confidence interval = 0.38-0.83) in men but not women with similar effects observed for diffuse large-cell and follicular lymphoma (FL). NHL risk also was reduced in men with the CCR2/CCR5 haplotype characterized by the CCR5 delta 32 deletion. The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings.</.

引用

页码：497 / 506

页数：10

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