Subunit Composition of Nicotinic Acetylcholine Receptors in Neurons of the Rat Intracardiac Ganglia

被引：0

作者：

Purnyn, H. E. ^{[1
]}

Skok, M. V. ^{[2
]}

Rikhalsky, O. V. ^{[1
]}

Skok, V. I. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Bogomolets Inst Physiol, Kiev, Ukraine

[2] Natl Acad Sci Ukraine, Palladin Inst Biochem, Kiev, Ukraine

来源：

NEUROPHYSIOLOGY | 2002年 / 34卷 / 2-3期

关键词：

nicotinic acetylcholine receptor; antibodies; alpha subunit; intracardiac ganglia;

D O I：

10.1023/A:1020719820522

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of antibodies against alpha 3, alpha 4, alpha 5, and alpha 7 subunits of neuronal nicotinic acetylcholine receptors (nAChR) on ACh-induced shifts of the membrane potential (ACh potentials) in neurons of the intracardiac ganglia of the rat left atrium were studied using intracellular recording. It was found that (i) antibodies against each of the above subunits caused only a partial block of the ACh potential; (ii) the blocking effect of each particular antibody could be observed only in some of the examined neurons; (iii) in all neurons under study the block caused by a single antibody was only partial; (iv) the blocking effects of two or more antibodies on the ACh potential recorded from the same neuron were additive. It is concluded that (1) each of the above nAChR subunits is present only in a part of the intracardiac neurons, and (2) each intracardiac neuron has nAChR composed of more than one a subunit.

引用

页码：210 / 212

页数：3

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