Synthesis of guanosine analogs bearing pendant alkylthiol tethers

被引：18

作者：

Gundlach, CW ^{[1
]}

Ryder, TR ^{[1
]}

Glick, GD ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 23期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)00868-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of three guanosine monomers substituted with alkylthiol chains at either carbon-8 or the 2'-hydroxyI is described. The ready accessibility of these monomers will facilitate the use of disulfide cross-links to study the Folding and dynamics of RNA and will also provide loci for conjugation of reporter groups. (C) 1997 Elsevier Science Ltd.

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页码：4039 / 4042

页数：4

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