Induction of Pyroptosis and Its Implications in Cancer Management

被引：160
作者：
Wang, Yan-Yang [1 ,2 ]
Liu, Xin-Lan [3 ]
Zhao, Ren [1 ,2 ]
机构：
[1] Ningxia Med Univ, Gen Hosp, Dept Radiat Oncol, Yinchuan, Peoples R China
[2] Ningxia Med Univ, Canc Inst, Yinchuan, Peoples R China
[3] Ningxia Med Univ, Gen Hosp, Dept Med Oncol, Yinchuan, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2019年 / 9卷
基金：
中国国家自然科学基金;
关键词：
pyroptosis; gasdermin D (GSDMD); gasdermin E (GSDME); cancer progression; therapeutic sensitivity; NONSYNDROMIC HEARING IMPAIRMENT; HOST-CELL DEATH; INFLAMMATORY CASPASES; MOLECULAR-MECHANISMS; DFNA5; GENE; INFLAMMASOMES; APOPTOSIS; ACTIVATION; CLEAVAGE; RNA;
D O I：
10.3389/fonc.2019.00971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral infection. Pyroptosis may affect all stages of carcinogenesis and has become a new topic in cancer research. In this review, we first briefly introduced pyroptosis. In the subsequent section, we discussed the induction of pyroptosis in cancer and its potential role as a promising target for cancer therapy. In addition, the biological characteristics of gasdermin D (GSDMD) and gasdermin E (GSDME), two important pyroptosis substrates, and their prognostic role in cancer management were reviewed. These results help us to understand the pathogenesis of cancer and develop new drugs, which based on pyroptosis modulation, for cancer patients.
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页数：10
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